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Details on Person GSDME (1-270) binds PIPs

Class:IdReaction:9647660
_displayNameGSDME (1-270) binds PIPs
_doReleaseTRUE
_timestamp2021-04-22 04:32:09
authored[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:9647682] Shamovsky, Veronica, 2019-06-03
edited[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
input[DefinedSet:5620974] PI4P,PI(4,5)P2,PIP3 [plasma membrane]
[EntityWithAccessionedSequence:9647689] GSDME(1-270) [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9686078] Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
modified[InstanceEdit:9697310] Shamovsky, Veronica, 2020-08-12
[InstanceEdit:9710272] Shamovsky, Veronica, 2020-12-25
[InstanceEdit:9715450] Shamovsky, Veronica, 2021-02-17
[InstanceEdit:9716570] Shamovsky, Veronica, 2021-02-22
[InstanceEdit:9716651] Shamovsky, Veronica, 2021-02-23
[InstanceEdit:9728823] Shamovsky, Veronica, 2021-04-22
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameGSDME (1-270) binds PIPs
output[Complex:9647679] GSDME (1-270):PIPs [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2021-03-23
reviewed[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17
[InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17
[InstanceEdit:9728818] Shao, Feng, 2021-04-22
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9647696] R-HSA-9647660.3
summation[Summation:9697309] Gasdermin E (GSDME/DFNA5) cleavage at D270 by caspase‑3 (CAS...
(hasEvent)[Pathway:5620971] Pyroptosis [Homo sapiens]
(normalReaction)[FailedReaction:9710468] GSDME variant does not bind PIPs [Homo sapiens]
(precedingEvent)[Reaction:9710254] GSDME oligomerizes [Homo sapiens]
(updatedInstance)[_UpdateTracker:9776095] Update Tracker - [Reaction:9647660] GSDME (1-270) binds PIPs - v77:[modifyText]
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No pathways have been reviewed or authored by GSDME (1-270) binds PIPs (9647660)