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Details on Person GSDMD (1-275) binds bacterial cardiolipin

Class:Id	Reaction:9647643
_displayName	GSDMD (1-275) binds bacterial cardiolipin
_doRelease	TRUE
_timestamp	2025-08-18 19:04:07
authored	[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9647682] Shamovsky, Veronica, 2019-06-03
edited	[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
input	[EntityWithAccessionedSequence:9647641] GSDMD(1-275) [cytosol] [Homo sapiens] [SimpleEntity:9647661] cardiolipin [plasma membrane]
isChimeric	FALSE
literatureReference	[LiteratureReference:9647685] Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores [LiteratureReference:9647674] Pore-forming activity and structural autoinhibition of the gasdermin family
modified	[InstanceEdit:9710272] Shamovsky, Veronica, 2020-12-25 [InstanceEdit:9715450] Shamovsky, Veronica, 2021-02-17 [InstanceEdit:9716570] Shamovsky, Veronica, 2021-02-22 [InstanceEdit:9716642] Shamovsky, Veronica, 2021-02-23 [InstanceEdit:9728823] Shamovsky, Veronica, 2021-04-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9963989] Shamovsky, Veronica, 2025-08-18
name	GSDMD (1-275) binds bacterial cardiolipin
output	[Complex:9647626] GSDMD(1-275):cardiolipin [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9647680] CASP1 cleaves GSDMD [Homo sapiens] [Reaction:448702] Caspase-1 active tetramer formation [Homo sapiens] [BlackBoxEvent:9710294] GSDMD expression mediated by IRF2, IRF1 [Homo sapiens] [BlackBoxEvent:9710106] ELANE cleaves GSDMD [Homo sapiens] [BlackBoxEvent:9710294] GSDMD expression mediated by IRF2, IRF1 [Homo sapiens] [BlackBoxEvent:9948146] CASP4 cleaves GSDMD [Homo sapiens] [BlackBoxEvent:9710294] GSDMD expression mediated by IRF2, IRF1 [Homo sapiens] [BlackBoxEvent:9947861] CASP4 autocatalysis on LPS micelles [Homo sapiens] [Reaction:9947908] CASP4 autocatalysis on the bacterial surface [Homo sapiens] [BlackBoxEvent:9947997] CASP5 cleaves GSDMD [Homo sapiens] [BlackBoxEvent:9710294] GSDMD expression mediated by IRF2, IRF1 [Homo sapiens] [BlackBoxEvent:9947849] CASP5 autocatalysis on LPS micelles [Homo sapiens]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17 [InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17 [InstanceEdit:9728818] Shao, Feng, 2021-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9647706] R-HSA-9647643.4
summation	[Summation:9647673] The N-terminal domain of gasdermin D (GSDMD(1-275), also kno...
(hasEvent)	[Pathway:5620971] Pyroptosis [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776240] Update Tracker - [Reaction:9647643] GSDMD (1-275) binds bacterial cardiolipin - v77:[modifyText]
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