Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person CASP3 cleaves GSDME

Class:Id	BlackBoxEvent:9647632
_displayName	CASP3 cleaves GSDME
_doRelease	TRUE
_timestamp	2021-04-22 04:31:29
authored	[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
catalystActivity	[CatalystActivity:114327] cysteine-type endopeptidase activity of Caspase-3 [cytosol]
catalystActivityReference	[CatalystActivityReference:9693527] cysteine-type endopeptidase activity of Caspase-3 [cytosol] Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9647682] Shamovsky, Veronica, 2019-06-03
edited	[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
input	[EntityWithAccessionedSequence:9647620] GSDME [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9686078] Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death [LiteratureReference:9686122] Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin [LiteratureReference:9710028] Gasdermin E suppresses tumour growth by activating anti-tumour immunity
modified	[InstanceEdit:9689632] Shamovsky, Veronica, 2020-05-21 [InstanceEdit:9693316] Shamovsky, Veronica, 2020-07-01 [InstanceEdit:9693528] Shamovsky, Veronica, 2020-07-02 [InstanceEdit:9710030] Shamovsky, Veronica, 2020-12-25 [InstanceEdit:9710316] Shamovsky, Veronica, 2020-12-28 [InstanceEdit:9715450] Shamovsky, Veronica, 2021-02-17 [InstanceEdit:9716570] Shamovsky, Veronica, 2021-02-22 [InstanceEdit:9728823] Shamovsky, Veronica, 2021-04-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CASP3 cleaves GSDME
output	[EntityWithAccessionedSequence:9647615] GSDME (271-496) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9647689] GSDME(1-270) [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9710306] GSDME expression mediated by TP53, TP63 [Homo sapiens] [Reaction:9710323] TP53 or TP63 binds the GSDME gene [Homo sapiens] [Reaction:418845] Activation of caspase-3 [Homo sapiens] [Reaction:373700] Caspase-9 binds DCC:DIP13alpha complex [Homo sapiens] [Reaction:114252] Cleavage of Procaspase-3 by the apoptosome [Homo sapiens] [Reaction:114259] Cleavage of Procaspase‑9 to caspase‑9 [Homo sapiens]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17 [InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17 [InstanceEdit:9728818] Shao, Feng, 2021-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9647710] R-HSA-9647632.3
summation	[Summation:9647646] Gasdermin E (GSDME, also known as DFNA5) was identified as a...
(hasEvent)	[Pathway:5620971] Pyroptosis [Homo sapiens]
(precedingEvent)	[Reaction:9647660] GSDME (1-270) binds PIPs [Homo sapiens] [Reaction:9710354] GSDME (1-270) binds cardiolipin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776138] Update Tracker - [BlackBoxEvent:9647632] CASP3 cleaves GSDME - v77:[modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by CASP3 cleaves GSDME (9647632)