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Details on Person GSDMD (1-275) binds PIPs

Class:IdReaction:9647631
_displayNameGSDMD (1-275) binds PIPs
_doReleaseTRUE
_timestamp2025-08-18 19:03:50
authored[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:9647682] Shamovsky, Veronica, 2019-06-03
edited[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
input[EntityWithAccessionedSequence:9647641] GSDMD(1-275) [cytosol] [Homo sapiens]
[DefinedSet:5620974] PI4P,PI(4,5)P2,PIP3 [plasma membrane]
isChimericFALSE
literatureReference[LiteratureReference:9647670] Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death
[LiteratureReference:9693533] Mechanism of membrane pore formation by human gasdermin-D
modified[InstanceEdit:9686081] Shamovsky, Veronica, 2020-04-28
[InstanceEdit:9710120] Shamovsky, Veronica, 2020-12-25
[InstanceEdit:9715450] Shamovsky, Veronica, 2021-02-17
[InstanceEdit:9716570] Shamovsky, Veronica, 2021-02-22
[InstanceEdit:9716651] Shamovsky, Veronica, 2021-02-23
[InstanceEdit:9728823] Shamovsky, Veronica, 2021-04-22
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9963577] Shamovsky, Veronica, 2025-08-14
[InstanceEdit:9963988] Shamovsky, Veronica, 2025-08-18
nameGSDMD (1-275) binds PIPs
output[Complex:9647692] GSDMD (1-275):PIPs [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2021-03-23
reviewed[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17
[InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17
[InstanceEdit:9728818] Shao, Feng, 2021-04-22
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9647700] R-HSA-9647631.4
summation[Summation:9647675] Human gasdermin D (GSDMD) is a member of the gasdermin (GSDM...
(hasEvent)[Pathway:5620971] Pyroptosis [Homo sapiens]
(precedingEvent)[Reaction:9647645] GSDMD oligomerizes into arc-, slit-shaped structures [Homo sapiens]
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No pathways have been reviewed or authored by GSDMD (1-275) binds PIPs (9647631)