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Details on Person p-6Y-ERBB2 H878Y [plasma membrane]

Class:Id	EntityWithAccessionedSequence:9647215
_displayName	p-6Y-ERBB2 H878Y [plasma membrane]
_timestamp	2019-08-01 15:27:09
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9647197] Orlic-Milacic, Marija, 2019-05-30
crossReference	[DatabaseIdentifier:9646843] COSMIC:COSV54066178
disease	[Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:2327993] hepatocellular carcinoma [Disease:9646847] urinary system cancer
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9646820] L-histidine 878 replaced with L-tyrosine [ModifiedResidue:1248700] O4'-phospho-L-tyrosine at 1023 [ModifiedResidue:1248685] O4'-phospho-L-tyrosine at 1139 [ModifiedResidue:1248708] O4'-phospho-L-tyrosine at 1196 [ModifiedResidue:1248692] O4'-phospho-L-tyrosine at 1221 [ModifiedResidue:1248701] O4'-phospho-L-tyrosine at 1222 [ModifiedResidue:1248689] O4'-phospho-L-tyrosine at 1248 [ModifiedResidue:9656347] O4'-phospho-L-tyrosine at 878
literatureReference	[LiteratureReference:9646964] Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor [LiteratureReference:9646962] Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity [LiteratureReference:9649397] Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib
modified	[InstanceEdit:9649412] Orlic-Milacic, Marija, 2019-06-13 [InstanceEdit:9656350] Orlic-Milacic, Marija, 2019-08-01
name	p-6Y-ERBB2 H878Y p-6Y-HER2 H878Y p-6Y-ERBB2 His878Tyr p-6Y-HER2 His878Tyr
referenceEntity	[ReferenceGeneProduct:54422] UniProt:P04626 ERBB2 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9647219] R-HSA-9647215.1
startCoordinate	23
(hasCandidate)	[CandidateSet:9647244] p-6Y-ERBB2 KD mutants [plasma membrane] [Homo sapiens]
(hasMember)	[CandidateSet:9654839] p-6Y-ERBB2 H878Y,(p-6Y-ERBB2 H878R) [plasma membrane] [Homo sapiens] [CandidateSet:9664610] p-6Y-ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] [Homo sapiens] [CandidateSet:9664920] p-6Y-ERBB2 KD mutants (EGFR,PI3K) [plasma membrane] [Homo sapiens] [CandidateSet:9664999] p-6Y-ERBB2 KD mutants (EGFR,RAS) [plasma membrane] [Homo sapiens] [CandidateSet:9665035] p-6Y-ERBB2 KD mutants (EGFR,PLCG1) [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by p-6Y-ERBB2 H878Y [plasma membrane] (9647215)