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Details on Person p-6Y-ERBB2 I767M [plasma membrane]

Class:Id	EntityWithAccessionedSequence:9647211
_displayName	p-6Y-ERBB2 I767M [plasma membrane]
_timestamp	2019-05-30 20:00:11
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9647197] Orlic-Milacic, Marija, 2019-05-30
crossReference	[DatabaseIdentifier:9646736] COSMIC:COSV54064925 [DatabaseIdentifier:9646738] COSMIC:COSM4422821
disease	[Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:1248674] large intestine cancer [Disease:9630862] esophagus squamous cell carcinoma [Disease:1500575] ovarian cancer [Disease:6802273] skin melanoma [Disease:1493885] bladder carcinoma [Disease:9632618] nasopharynx carcinoma [Disease:1655480] salivary gland cancer
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9646735] L-isoleucine 767 replaced with L-methionine [ModifiedResidue:1248700] O4'-phospho-L-tyrosine at 1023 [ModifiedResidue:1248685] O4'-phospho-L-tyrosine at 1139 [ModifiedResidue:1248708] O4'-phospho-L-tyrosine at 1196 [ModifiedResidue:1248692] O4'-phospho-L-tyrosine at 1221 [ModifiedResidue:1248701] O4'-phospho-L-tyrosine at 1222 [ModifiedResidue:1248689] O4'-phospho-L-tyrosine at 1248
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer [LiteratureReference:9646758] Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification
name	p-6Y-ERBB2 I767M p-6Y-HER2 I767M p-6Y-ERBB2 Ile767Met p-6Y-HER2 Ile767Met
referenceEntity	[ReferenceGeneProduct:54422] UniProt:P04626 ERBB2 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9647241] R-HSA-9647211.1
startCoordinate	23
(hasComponent)	[Complex:9654299] Phosphorylated ERBB2 I767M:ERBB4cyt2 heterodimer [plasma membrane] [Homo sapiens] [Complex:9654309] Phosphorylated ERBB2 I767M:EGFR heterodimer [plasma membrane] [Homo sapiens] [Complex:9654320] Phosphorylated ERBB2 I767M:ERBB4cyt1 heterodimers [plasma membrane] [Homo sapiens]
(hasMember)	[CandidateSet:9647244] p-6Y-ERBB2 KD mutants [plasma membrane] [Homo sapiens] [CandidateSet:9664610] p-6Y-ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] [Homo sapiens] [CandidateSet:9664920] p-6Y-ERBB2 KD mutants (EGFR,PI3K) [plasma membrane] [Homo sapiens] [CandidateSet:9664999] p-6Y-ERBB2 KD mutants (EGFR,RAS) [plasma membrane] [Homo sapiens] [CandidateSet:9665035] p-6Y-ERBB2 KD mutants (EGFR,PLCG1) [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by p-6Y-ERBB2 I767M [plasma membrane] (9647211)