Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person p-6Y-ERBB2 L755M [plasma membrane]

Class:IdEntityWithAccessionedSequence:9647204
_displayNamep-6Y-ERBB2 L755M [plasma membrane]
_timestamp2019-05-30 20:00:11
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9647197] Orlic-Milacic, Marija, 2019-05-30
crossReference[DatabaseIdentifier:9646520] COSMIC:COSV54062219
disease[Disease:1500689] cancer
[Disease:1500576] breast cancer
[Disease:6802273] skin melanoma
[Disease:1248674] large intestine cancer
endCoordinate1255
hasModifiedResidue[ReplacedResidue:9646535] L-leucine 755 replaced with L-methionine
[ModifiedResidue:1248700] O4'-phospho-L-tyrosine at 1023
[ModifiedResidue:1248685] O4'-phospho-L-tyrosine at 1139
[ModifiedResidue:1248708] O4'-phospho-L-tyrosine at 1196
[ModifiedResidue:1248692] O4'-phospho-L-tyrosine at 1221
[ModifiedResidue:1248701] O4'-phospho-L-tyrosine at 1222
[ModifiedResidue:1248689] O4'-phospho-L-tyrosine at 1248
literatureReference[LiteratureReference:9646515] Pyrosequencing-Based Assays for Rapid Detection of HER2 and HER3 Mutations in Clinical Samples Uncover an E332E Mutation Affecting HER3 in Retroperitoneal Leiomyosarcoma
namep-6Y-ERBB2 L755M
p-6Y-HER2 L755M
p-6Y-ERBB2 Leu755Met
p-6Y-HER2 Leu755Met
referenceEntity[ReferenceGeneProduct:54422] UniProt:P04626 ERBB2 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9647240] R-HSA-9647204.1
startCoordinate23
(hasCandidate)[CandidateSet:9647244] p-6Y-ERBB2 KD mutants [plasma membrane] [Homo sapiens]
[CandidateSet:9654197] p-6Y-ERBB2 L755S,(p-6Y-ERBB2 L755M,p-6Y-ERBB2 L755W) [plasma membrane] [Homo sapiens]
[CandidateSet:9664610] p-6Y-ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] [Homo sapiens]
[CandidateSet:9664920] p-6Y-ERBB2 KD mutants (EGFR,PI3K) [plasma membrane] [Homo sapiens]
[CandidateSet:9664999] p-6Y-ERBB2 KD mutants (EGFR,RAS) [plasma membrane] [Homo sapiens]
[CandidateSet:9665035] p-6Y-ERBB2 KD mutants (EGFR,PLCG1) [plasma membrane] [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by p-6Y-ERBB2 L755M [plasma membrane] (9647204)