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Details on Person p-6Y-ERBB2 L755P [plasma membrane]

Class:Id	EntityWithAccessionedSequence:9647196
_displayName	p-6Y-ERBB2 L755P [plasma membrane]
_timestamp	2019-05-30 20:00:10
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9647197] Orlic-Milacic, Marija, 2019-05-30
crossReference	[DatabaseIdentifier:9646496] COSMIC:COSV54069116 [DatabaseIdentifier:9646524] COSMIC:COSM6907352
disease	[Disease:1500689] cancer [Disease:1500699] lung cancer
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9646492] L-leucine 755 replaced with L-proline [ModifiedResidue:1248700] O4'-phospho-L-tyrosine at 1023 [ModifiedResidue:1248685] O4'-phospho-L-tyrosine at 1139 [ModifiedResidue:1248708] O4'-phospho-L-tyrosine at 1196 [ModifiedResidue:1248692] O4'-phospho-L-tyrosine at 1221 [ModifiedResidue:1248701] O4'-phospho-L-tyrosine at 1222 [ModifiedResidue:1248689] O4'-phospho-L-tyrosine at 1248
literatureReference	[LiteratureReference:9646493] Atomistic insights into the lung cancer-associated L755P mutation in HER2 resistance to lapatinib: a molecular dynamics study
name	p-6Y-ERBB2 L755P p-6Y-HER2 L755P p-6Y-ERBB2 Leu755Pro p-6Y-HER2 Leu755Pro
referenceEntity	[ReferenceGeneProduct:54422] UniProt:P04626 ERBB2 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9647232] R-HSA-9647196.1
startCoordinate	23
(hasCandidate)	[CandidateSet:9647244] p-6Y-ERBB2 KD mutants [plasma membrane] [Homo sapiens]
(hasComponent)	[Complex:9654263] Phosphorylated ERBB2 L755P:ERBB4cyt2 heterodimer [plasma membrane] [Homo sapiens] [Complex:9654266] Phosphorylated ERBB2 L755P:ERBB4cyt1 heterodimers [plasma membrane] [Homo sapiens] [Complex:9654269] Phosphorylated ERBB2 L755P:EGFR heterodimer [plasma membrane] [Homo sapiens]
(hasMember)	[CandidateSet:9664610] p-6Y-ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] [Homo sapiens] [CandidateSet:9664920] p-6Y-ERBB2 KD mutants (EGFR,PI3K) [plasma membrane] [Homo sapiens] [CandidateSet:9664999] p-6Y-ERBB2 KD mutants (EGFR,RAS) [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by p-6Y-ERBB2 L755P [plasma membrane] (9647196)