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Details on Person p-6Y-ERBB2 T733I [plasma membrane]

Class:Id	EntityWithAccessionedSequence:9647195
_displayName	p-6Y-ERBB2 T733I [plasma membrane]
_timestamp	2019-05-30 20:00:10
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9647197] Orlic-Milacic, Marija, 2019-05-30
crossReference	[DatabaseIdentifier:9646766] COSMIC:COSV54064293
disease	[Disease:1500689] cancer [Disease:2327989] bile duct carcinoma [Disease:2317358] endometrial cancer [Disease:1248674] large intestine cancer [Disease:1500687] stomach cancer [Disease:1493885] bladder carcinoma
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9646761] L-threonine 733 replaced with L-isoleucine [ModifiedResidue:1248700] O4'-phospho-L-tyrosine at 1023 [ModifiedResidue:1248685] O4'-phospho-L-tyrosine at 1139 [ModifiedResidue:1248708] O4'-phospho-L-tyrosine at 1196 [ModifiedResidue:1248692] O4'-phospho-L-tyrosine at 1221 [ModifiedResidue:1248701] O4'-phospho-L-tyrosine at 1222 [ModifiedResidue:1248689] O4'-phospho-L-tyrosine at 1248
literatureReference	[LiteratureReference:9646776] EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation
name	p-6Y-ERBB2 T733I p-6Y-HER2 T733I p-6Y-ERBB2 Thr733Ile p-6Y-HER2 Thr733Ile
referenceEntity	[ReferenceGeneProduct:54422] UniProt:P04626 ERBB2 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9647227] R-HSA-9647195.1
startCoordinate	23
(hasCandidate)	[CandidateSet:9647244] p-6Y-ERBB2 KD mutants [plasma membrane] [Homo sapiens] [CandidateSet:9654617] p-6Y-ERBB2 T798I,p-6Y-ERBB2 T798M,(p-6Y-ERBB2 T733I) [plasma membrane] [Homo sapiens] [CandidateSet:9664610] p-6Y-ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] [Homo sapiens] [CandidateSet:9664920] p-6Y-ERBB2 KD mutants (EGFR,PI3K) [plasma membrane] [Homo sapiens] [CandidateSet:9664999] p-6Y-ERBB2 KD mutants (EGFR,RAS) [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by p-6Y-ERBB2 T733I [plasma membrane] (9647195)