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Details on Person ERBB2 KD mutant heterodimers trans-autophosphorylate

Class:IdReaction:9647036
_displayNameERBB2 KD mutant heterodimers trans-autophosphorylate
_doReleaseFALSE
_timestamp2019-06-18 20:31:44
catalystActivity[CatalystActivity:9647247] protein tyrosine kinase activity of ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:9647037] Orlic-Milacic, Marija, 2019-05-30
entityFunctionalStatus[EntityFunctionalStatus:9647045] gain_of_function of ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane]
input[CandidateSet:9646501] ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
modified[InstanceEdit:9647052] Orlic-Milacic, Marija, 2019-05-30
[InstanceEdit:9647242] Orlic-Milacic, Marija, 2019-05-30
[InstanceEdit:9647251] Orlic-Milacic, Marija, 2019-05-30
[InstanceEdit:9649931] Orlic-Milacic, Marija, 2019-06-18
[InstanceEdit:9649942] Orlic-Milacic, Marija, 2019-06-18
[InstanceEdit:9831316] Orlic-Milacic, Marija, 2023-03-20
nameERBB2 KD mutant heterodimers trans-autophosphorylate
normalReaction
output[CandidateSet:9647249] p-6Y-ERBB2 KD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
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[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
regulatedBy[NegativeRegulation:9649929] Negative regulation by 'ERBB2 KD mutants (trastuzumab sensitive):trastuzumab [plasma membrane]'
[NegativeRegulation:9649938] Negative regulation by 'Afatinib:ERBB2 KD mutant heterodimers [plasma membrane]'
[NegativeRegulation:9649932] Negative regulation by 'Lapatinib:ERBB2 KD mutant heterodimers [plasma membrane]'
[NegativeRegulation:9649941] Negative regulation by 'Neratinib:ERBB2 KD mutant heterodimers [plasma membrane]'
[NegativeRegulation:9649939] Negative regulation by 'Osimertinib:ERBB2 KD mutant heterodimers [plasma membrane]'
[NegativeRegulation:9649935] Negative regulation by 'AZ5104:ERBB2 KD mutant dimers [plasma membrane]'
[NegativeRegulation:9649937] Negative regulation by 'Tesevatinib:ERBB2 KD mutant heterodimers [plasma membrane]'
[NegativeRegulation:9649933] Negative regulation by 'Sapitinib:ERBB2 KD mutant heterodimers [plasma membrane]'
[NegativeRegulation:9649934] Negative regulation by 'Canertinib:ERBB2 H878Y heterodimers [plasma membrane]'
[NegativeRegulation:9649936] Negative regulation by 'CP-724714:ERBB2 H878Y heterodimers [plasma membrane]'
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9647038] R-HSA-9647036.1
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No pathways have been reviewed or authored by ERBB2 KD mutant heterodimers trans-autophosphorylate (9647036)