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Details on Person EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation
| Class:Id | LiteratureReference:9646776 |
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| _displayName | EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation |
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| _timestamp | 2019-05-28 17:50:08 |
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| author | [Person:9646764] Trowe, Torsten
[Person:9646768] Boukouvala, Sotiria
[Person:9646771] Calkins, Keith
[Person:5672167] Cutler, Richard E
[Person:9646767] Fong, Ryan
[Person:9646772] Funke, Roel
[Person:9646774] Gendreau, Steven B
[Person:9646773] Kim, Yong D
[Person:2328207] Miller, Nicole
[Person:9646760] Woolfrey, John R
[Person:9646777] Vysotskaia, Valentina
[Person:9646763] Yang, Jing Ping
[Person:1268065] Gerritsen, ME
[Person:9646770] Matthews, David J
[Person:9646762] Lamb, Peter
[Person:9646775] Heuer, Timothy S |
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| created | [InstanceEdit:9646769] Orlic-Milacic, Marija, 2019-05-28 |
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| journal | Clin. Cancer Res. |
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| pages | 2465-75 |
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| pubMedIdentifier | 18413839 |
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| title | EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation |
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| volume | 14 |
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| year | 2008 |
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| (literatureReference) | [Pathway:9664565] Signaling by ERBB2 KD Mutants [Homo sapiens]
[Reaction:9664588] ERBB2 KD mutants trans-autophosphorylate [Homo sapiens]
[Reaction:9664950] Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1 [Homo sapiens]
[Reaction:9664976] Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1 [Homo sapiens]
[Reaction:9664983] Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1 [Homo sapiens]
[Reaction:9664991] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants [Homo sapiens]
[Reaction:9665000] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1 [Homo sapiens]
[Reaction:9665009] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR [Homo sapiens]
[Reaction:9665121] ERBB2 KD mutants bind TKIs [Homo sapiens]
[Pathway:9665245] Resistance of ERBB2 KD mutants to tesevatinib [Homo sapiens] |
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No pathways have been reviewed or authored by EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation (9646776)
