Query author contributions in Reactome Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
expertise and time to the Reactome curation process. More information is available at
ORCID and Reactome .
If you have an ORCID ID that is not listed on this page, please
forward this information to us and we will update your Reactome pathway records.
Details on Person ERBB2 V842I [plasma membrane]
Class:Id EntityWithAccessionedSequence:9646703
_displayName ERBB2 V842I [plasma membrane]
_timestamp 2019-05-28 16:36:44
compartment [Compartment:876] plasma membrane
created [InstanceEdit:9646702] Orlic-Milacic, Marija, 2019-05-28
crossReference [DatabaseIdentifier:9646706] COSMIC:COSV54062791 [DatabaseIdentifier:9646709] COSMIC:COSM1666633
disease [Disease:1500689] cancer [Disease:9630851] gallbladder adenocarcinoma [Disease:2327989] bile duct carcinoma [Disease:1500576] breast cancer [Disease:2317358] endometrial cancer [Disease:9631134] cervical squamous cell carcinoma [Disease:1248674] large intestine cancer [Disease:9632339] esophagus adenocarcinoma [Disease:1500575] ovarian cancer [Disease:2328198] pancreatic cancer [Disease:1655494] prostate adenocarcinoma [Disease:3310977] small intestine carcinoma [Disease:1500687] stomach cancer [Disease:2327997] pharynx cancer [Disease:1493885] bladder carcinoma [Disease:1655480] salivary gland cancer [Disease:2317371] ovarian endometrioid neoplasm
endCoordinate 1255
hasModifiedResidue [ReplacedResidue:9646701] L-valine 842 replaced with L-isoleucine
literatureReference [LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
modified [InstanceEdit:9646712] Orlic-Milacic, Marija, 2019-05-28 [InstanceEdit:9646713] Orlic-Milacic, Marija, 2019-05-28 [InstanceEdit:9646718] Orlic-Milacic, Marija, 2019-05-28
name ERBB2 V842I HER2 V842I ERBB2 Val842Ile HER2 Val842Ile
referenceEntity [ReferenceGeneProduct:54422] UniProt:P04626 ERBB2 [Homo sapiens]
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:9646704] R-HSA-9646703.1
startCoordinate 23
(hasCandidate) [CandidateSet:9649470] ERBB2 KD mutants (sapitinib) [plasma membrane] [Homo sapiens]
(hasComponent) [Complex:9655250] ERBB2 V842I:ERBB4cyt1 heterodimers [plasma membrane] [Homo sapiens] [Complex:9655252] ERBB2 V842I:ERBB4cyt2 heterodimer [plasma membrane] [Homo sapiens] [Complex:9655254] EGF:EGFR:ERBB2 V842I [plasma membrane] [Homo sapiens] [Complex:9655255] NRG1/2:ERBB3:ERBB2 V842I [plasma membrane] [Homo sapiens]
(hasMember) [CandidateSet:9646481] ERBB2 KD mutants [plasma membrane] [Homo sapiens] [CandidateSet:9649436] ERBB2 KD mutants (neratinib) [plasma membrane] [Homo sapiens] [CandidateSet:9649456] ERBB2 KD mutants (osimertinib) [plasma membrane] [Homo sapiens] [CandidateSet:9649458] ERBB2 KD mutants (afatinib) [plasma membrane] [Homo sapiens] [CandidateSet:9652385] ERBB2 V842I,(ERBB2 V842E) [plasma membrane] [Homo sapiens] [CandidateSet:9664578] ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] [Homo sapiens] [CandidateSet:9665226] ERBB2 KD mutants (trastuzumab resistant) [plasma membrane] [Homo sapiens] [CandidateSet:9665282] ERBB2 KD mutants (lapatinib resistant) [plasma membrane] [Homo sapiens]
[Change default viewing format]
List...
Pathways
No pathways have been reviewed or authored by ERBB2 V842I [plasma membrane] (9646703)