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Details on Person ERBB2 D769H [plasma membrane]

Class:IdEntityWithAccessionedSequence:9646617
_displayNameERBB2 D769H [plasma membrane]
_timestamp2019-05-29 19:09:44
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9646616] Orlic-Milacic, Marija, 2019-05-27
crossReference[DatabaseIdentifier:9646614] COSMIC:COSV54062425
[DatabaseIdentifier:9646613] COSMIC:COSM4775196
disease[Disease:1500689] cancer
[Disease:1500576] breast cancer
[Disease:9631134] cervical squamous cell carcinoma
[Disease:1500687] stomach cancer
[Disease:2317371] ovarian endometrioid neoplasm
[Disease:1493885] bladder carcinoma
endCoordinate1255
hasModifiedResidue[ReplacedResidue:9646615] L-aspartic acid 769 replaced with L-histidine
literatureReference[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
modified[InstanceEdit:9647029] Orlic-Milacic, Marija, 2019-05-29
nameERBB2 D769H
HER2 D769H
ERBB2 Asp769His
HER2 Asp769His
referenceEntity[ReferenceGeneProduct:54422] UniProt:P04626 ERBB2 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9646618] R-HSA-9646617.1
startCoordinate23
(hasComponent)[Complex:9655122] ERBB2 D769H:ERBB4cyt2 heterodimer [plasma membrane] [Homo sapiens]
[Complex:9655125] ERBB2 D769H:ERBB4cyt1 heterodimers [plasma membrane] [Homo sapiens]
[Complex:9655129] EGF:EGFR:ERBB2 D769H [plasma membrane] [Homo sapiens]
[Complex:9655130] NRG1/2:ERBB3:ERBB2 D769H [plasma membrane] [Homo sapiens]
(hasMember)[CandidateSet:9646481] ERBB2 KD mutants [plasma membrane] [Homo sapiens]
[CandidateSet:9649436] ERBB2 KD mutants (neratinib) [plasma membrane] [Homo sapiens]
[CandidateSet:9649439] ERBB2 KD mutants (lapatinib) [plasma membrane] [Homo sapiens]
[CandidateSet:9649456] ERBB2 KD mutants (osimertinib) [plasma membrane] [Homo sapiens]
[CandidateSet:9649458] ERBB2 KD mutants (afatinib) [plasma membrane] [Homo sapiens]
[DefinedSet:9649468] ERBB2 KD mutants (trastuzumab) [plasma membrane] [Homo sapiens]
[CandidateSet:9649470] ERBB2 KD mutants (sapitinib) [plasma membrane] [Homo sapiens]
[CandidateSet:9652387] ERBB2 D769H,(ERBB2 D769Y,ERBB2 D769N) [plasma membrane] [Homo sapiens]
[CandidateSet:9664578] ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by ERBB2 D769H [plasma membrane] (9646617)