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Details on Person ERBB2 V777M [plasma membrane]

Class:IdEntityWithAccessionedSequence:9646591
_displayNameERBB2 V777M [plasma membrane]
_timestamp2019-05-29 18:43:42
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9646588] Orlic-Milacic, Marija, 2019-05-27
crossReference[DatabaseIdentifier:9646590] COSMIC:COSV54069186
[DatabaseIdentifier:9646592] COSMIC:COSM4775193
disease[Disease:1500576] breast cancer
[Disease:1500689] cancer
[Disease:1248674] large intestine cancer
[Disease:1500687] stomach cancer
[Disease:1493885] bladder carcinoma
endCoordinate1255
hasModifiedResidue[ReplacedResidue:9646587] L-valine 777 replaced with L-methionine
literatureReference[LiteratureReference:9647018] Nonamplification ERBB2 genomic alterations in 5605 cases of recurrent and metastatic breast cancer: An emerging opportunity for anti-HER2 targeted therapies
[LiteratureReference:9647024] Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas
[LiteratureReference:9646931] Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
modified[InstanceEdit:9647027] Orlic-Milacic, Marija, 2019-05-29
nameERBB2 V777M
HER2 V777M
ERBB2 Val777Met
HER2 Val777Met
referenceEntity[ReferenceGeneProduct:54422] UniProt:P04626 ERBB2 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9646593] R-HSA-9646591.1
startCoordinate23
(hasCandidate)[CandidateSet:9646481] ERBB2 KD mutants [plasma membrane] [Homo sapiens]
[CandidateSet:9649470] ERBB2 KD mutants (sapitinib) [plasma membrane] [Homo sapiens]
[CandidateSet:9652377] ERBB2 V777L,(ERBB2 V777M,ERBB2 V777E) [plasma membrane] [Homo sapiens]
[CandidateSet:9664578] ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] [Homo sapiens]
(hasComponent)[Complex:9655155] ERBB2 V777M:ERBB4cyt2 heterodimer [plasma membrane] [Homo sapiens]
[Complex:9655157] ERBB2 V777M:ERBB4cyt1 heterodimers [plasma membrane] [Homo sapiens]
[Complex:9655160] EGF:EGFR:ERBB2 V777M [plasma membrane] [Homo sapiens]
[Complex:9655163] NRG1/2:ERBB3:ERBB2 V777M [plasma membrane] [Homo sapiens]
(hasMember)[CandidateSet:9649436] ERBB2 KD mutants (neratinib) [plasma membrane] [Homo sapiens]
[CandidateSet:9649439] ERBB2 KD mutants (lapatinib) [plasma membrane] [Homo sapiens]
[CandidateSet:9649456] ERBB2 KD mutants (osimertinib) [plasma membrane] [Homo sapiens]
[CandidateSet:9649458] ERBB2 KD mutants (afatinib) [plasma membrane] [Homo sapiens]
[DefinedSet:9649468] ERBB2 KD mutants (trastuzumab) [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by ERBB2 V777M [plasma membrane] (9646591)
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