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Details on Person mTORC1 binds RHEB:GTP

Class:Id	Reaction:9646468
_displayName	mTORC1 binds RHEB:GTP
_doRelease	TRUE
_timestamp	2019-08-08 18:50:14
authored	[InstanceEdit:9646460] May, Bruce, 2019-05-24
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:9646459] May, Bruce, 2019-05-24
edited	[InstanceEdit:9646460] May, Bruce, 2019-05-24
input	[Complex:9645607] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] [Homo sapiens] [Complex:165189] RHEB:GTP [lysosomal membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:376999] Rheb binds and regulates the mTOR kinase [LiteratureReference:9646563] Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency [LiteratureReference:9647571] Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1 [LiteratureReference:9647564] The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1 [LiteratureReference:9647561] Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
modified	[InstanceEdit:9646574] May, Bruce, 2019-05-25 [InstanceEdit:9647573] May, Bruce, 2019-06-01 [InstanceEdit:9657681] May, Bruce, 2019-08-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	mTORC1 binds RHEB:GTP
output	[Complex:9646467] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] [Homo sapiens]
precedingEvent	[Reaction:9645608] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 [Homo sapiens] [Reaction:9640168] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine [Homo sapiens]
releaseDate	2019-09-10
reviewed	[InstanceEdit:9657680] Condon, Kendall J, Sabatini, David M, 2019-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9646474] R-HSA-9646468.2
summation	[Summation:9647565] RHEB:GTP interacts with mTORC1 and activates the kinase acti...
(hasEvent)	[Pathway:9639288] Amino acids regulate mTORC1 [Homo sapiens]
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No pathways have been reviewed or authored by mTORC1 binds RHEB:GTP (9646468)