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Details on Person RHEB:GTP hydrolyzes GTP
Class:Id Reaction:9646464 _displayName RHEB:GTP hydrolyzes GTP _timestamp 2019-06-28 08:49:46 authored [InstanceEdit:9646460] May, Bruce, 2019-05-24 catalystActivity [CatalystActivity:9647605] GTPase activity of v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP:mTORC1:RHEB:GTP:TSC [lysosomal membrane] compartment [Compartment:17938] lysosomal membrane created [InstanceEdit:9646459] May, Bruce, 2019-05-24 edited [InstanceEdit:9646460] May, Bruce, 2019-05-24 input [Complex:9646466] v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP:mTORC1:RHEB:GTP:TSC [lysosomal membrane] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:5672044] TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1 [LiteratureReference:9646568] The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues [LiteratureReference:532191] Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb [LiteratureReference:110492] Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. [LiteratureReference:377025] Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity [LiteratureReference:532189] Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling [LiteratureReference:5632718] Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning modified [InstanceEdit:9646574] May, Bruce, 2019-05-25 [InstanceEdit:9647611] May, Bruce, 2019-06-02 [InstanceEdit:9647734] May, Bruce, 2019-06-03 [InstanceEdit:9652209] May, Bruce, 2019-06-28 name RHEB:GTP hydrolyzes GTP output [SimpleEntity:29372] Pi [cytosol] [Complex:9646458] v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP:mTORC1:RHEB:GDP:TSC [lysosomal membrane] [Homo sapiens] precedingEvent
regulatedBy [PositiveRegulation:9647609] Positive regulation by 'v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP:mTORC1:RHEB:GTP:TSC [lysosomal membrane]' regulationReference [RegulationReference:9647720] Positive regulation by 'v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP:mTORC1:RHEB:GTP:TSC [lysosomal membrane]' Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9646470] R-HSA-9646464.1 summation [Summation:9646545] The TSC complex (TSC1:TSC2:TBC1D7, Dibble et al. 2012) is a ... (precedingEvent) [Reaction:9646461] v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP:mTORC1:RHEB:GDP:TSC dissociates yielding cytosolic mTORC1 [Homo sapiens]
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No pathways have been reviewed or authored by RHEB:GTP hydrolyzes GTP (9646464)
