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Details on Person When the proteasome machinery is deregulated, misfolded prot...
| Class:Id | Summation:9646352 |
|---|---|
| _displayName | When the proteasome machinery is deregulated, misfolded prot... |
| _timestamp | 2019-06-14 15:03:51 |
| created | [InstanceEdit:9646355] Varusai, Thawfeek, 2019-05-23 |
| modified | [InstanceEdit:9646379] Varusai, Thawfeek, 2019-05-23 [InstanceEdit:9649433] Varusai, Thawfeek, 2019-06-14 |
| text | When the proteasome machinery is deregulated, misfolded proteins are eliminated by forming aggresomes. To this end, poly-ubiquitinated misfolded proteins bind to a complex comprising of Transitional endoplasmic reticulum ATPase (VCP), Histone deacetylase 6 (HDAC6), Heat shock protein HSP 90 (HSP90) and Heat shock factor protein 1 (HSF1). HDAC6 in the complex interacts with the ubiquitin molecules in the misfolded proteins. Following this binding event, this complex starts dissociating (Boyault C et al. 2007). |
| (summation) | [Reaction:9646347] PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 [Homo sapiens] |
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No pathways have been reviewed or authored by When the proteasome machinery is deregulated, misfolded prot... (9646352)
