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Details on Person Cancer-derived missense mutations in the CDKN2A gene that af...
| Class:Id | Summation:9645778 |
|---|---|
| _displayName | Cancer-derived missense mutations in the CDKN2A gene that af... |
| _timestamp | 2019-05-22 18:51:15 |
| created | [InstanceEdit:9645779] Orlic-Milacic, Marija, 2019-05-17 |
| modified | [InstanceEdit:9645805] Orlic-Milacic, Marija, 2019-05-17 [InstanceEdit:9646336] Orlic-Milacic, Marija, 2019-05-22 |
| text | Cancer-derived missense mutations in the CDKN2A gene that affect the C-terminal arginine-rich region of p14ARF (also known as CDKN2A transcription isoform 4, CDKN2A-4, p14 or ARF) impair p14ARF binding to the mitochondrial matrix protein C1QBP and interfere with p53-mediated apoptosis. Many mutations in the CDKN2A locus that affect C-terminal arginines of p14ARF are silent in p16INK4A (CDKN2A-1) (Itahana and Zhang 2008). |
| (summation) | [Pathway:9645722] Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function [Homo sapiens] |
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No pathways have been reviewed or authored by Cancer-derived missense mutations in the CDKN2A gene that af... (9645778)
