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Details on Person v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1

Class:Id	Reaction:9645608
_displayName	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
_doRelease	TRUE
_timestamp	2019-08-08 18:50:19
authored	[InstanceEdit:9645605] May, Bruce, 2019-05-13
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:9645606] May, Bruce, 2019-05-13
edited	[InstanceEdit:9645605] May, Bruce, 2019-05-13
input	[Complex:9639277] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] [Homo sapiens] [Complex:377400] mTORC1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5653951] The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1 [LiteratureReference:5653913] Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids [LiteratureReference:9646240] A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold [LiteratureReference:9646571] Regulation of TORC1 by Rag GTPases in nutrient response [LiteratureReference:9646570] mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
modified	[InstanceEdit:9646273] May, Bruce, 2019-05-20 [InstanceEdit:9646574] May, Bruce, 2019-05-25 [InstanceEdit:9657681] May, Bruce, 2019-08-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
output	[Complex:9645607] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] [Homo sapiens]
precedingEvent	[Reaction:9640168] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine [Homo sapiens] [Reaction:9640167] RRAGA,B exchanges GDP for GTP [Homo sapiens]
releaseDate	2019-09-10
reviewed	[InstanceEdit:9657680] Condon, Kendall J, Sabatini, David M, 2019-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9645609] R-HSA-9645608.2
summation	[Summation:9646265] The heterodimer comprising RRAGA,B:GTP and RRAGC,D:GDP (RagA...
(hasEvent)	[Pathway:9639288] Amino acids regulate mTORC1 [Homo sapiens]
(precedingEvent)	[Reaction:9646468] mTORC1 binds RHEB:GTP [Homo sapiens]
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