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Details on Person Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex

Class:Id	Reaction:9645442
_displayName	Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
_doRelease	TRUE
_timestamp	2020-02-24 17:45:11
authored	[InstanceEdit:9645656] Shamovsky, Veronica, 2019-05-17
catalystActivity	[CatalystActivity:9645465] MAP kinase kinase kinase kinase activity of ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9645472] Shamovsky, Veronica, 2019-05-12
edited	[InstanceEdit:9657757] Shamovsky, Veronica, 2019-08-09
input	[Complex:9645445] ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:450183] TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop [LiteratureReference:438014] Essential function for the kinase TAK1 in innate and adaptive immune responses [LiteratureReference:433972] TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo [LiteratureReference:169931] TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction [LiteratureReference:2586644] Structural basis for the interaction of TAK1 kinase with its activating protein TAB1 [LiteratureReference:2586636] Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1 [LiteratureReference:2586622] An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK
modified	[InstanceEdit:9651311] Shamovsky, Veronica, 2019-06-25 [InstanceEdit:9652833] Shamovsky, Veronica, 2019-07-08 [InstanceEdit:9657761] Shamovsky, Veronica, 2019-08-09 [InstanceEdit:9658255] Shamovsky, Veronica, 2019-08-12 [InstanceEdit:9676969] Shamovsky, Veronica, 2020-02-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:9645449] ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) [Homo sapiens] [Polymerisation:9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation [Homo sapiens]
releaseDate	2019-09-10
reviewed	[InstanceEdit:9647756] Gillespie, Marc E, 2019-06-03 [InstanceEdit:9652842] Shao, Feng, 2019-07-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9645557] R-HSA-9645442.3
summation	[Summation:9645409] The TAK1 complex consists of transforming growth factor-beta...
(hasEvent)	[Pathway:9645460] Alpha-protein kinase 1 signaling pathway [Homo sapiens]
(precedingEvent)	[Reaction:168184] Activated TAK1 mediates phosphorylation of the IKK Complex [Homo sapiens] [Reaction:9757952] Activated TAK1 phosphorylates IKBKB [Homo sapiens]
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No pathways have been reviewed or authored by Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (9645442)