Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person TRAF-interacting protein with a forkhead-associated (FHA) do...
| Class:Id | Summation:9645401 |
|---|---|
| _displayName | TRAF-interacting protein with a forkhead-associated (FHA) do... |
| _timestamp | 2019-07-08 20:12:01 |
| created | [InstanceEdit:9645472] Shamovsky, Veronica, 2019-05-12 |
| literatureReference | [LiteratureReference:9645451] Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose [LiteratureReference:9645491] ADP-heptose is a newly identified pathogen-associated molecular pattern of Shigella flexneri [LiteratureReference:9645486] ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria [LiteratureReference:9645483] ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System [LiteratureReference:9645436] Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway [LiteratureReference:9645381] TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection [LiteratureReference:9645463] TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6 [LiteratureReference:9645437] INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity [LiteratureReference:9645430] Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-κB activation |
| modified | [InstanceEdit:9645656] Shamovsky, Veronica, 2019-05-17 [InstanceEdit:9652833] Shamovsky, Veronica, 2019-07-08 |
| text | TRAF-interacting protein with a forkhead-associated (FHA) domain (TIFA) was reported to trigger NF-kappa B mediated inflammatory responses to Helicobacter pylori, Shigella flexneri, Yersinia pseudotuberculosis infections (Gall A et al. 2017; Milivojevic M et al. 2017; Gaudet RG et al. 2017; García‐Weber D et al. 2018; Zhou P et al. 2018). During infection, ADP-heptose-activated alpha protein kinase 1 (ALPK1) binds and phosphorylates TIFA at threonine 9 (T9) (Zhou P et al. 2018). Defective NF-κB activation in TIFA -/- human embryonic kidney 293T (HEK293T) cells was restored by wild-type TIFA but not by the non-phosphorylatable T9A TIFA variant upon H. pylori, S. flexneri, Y. pseudotuberculosis infections (Zimmermann S et al. 2017; Gaudet RG et al. 2017; Zhou P et al. 2018). Moreover, T9A TIFA variant was unable to oligomerize preventing the S. flexneri- induced formation of the TIFA:TRAF6:TAK1-Ub complex in TIFA -/- HEK293T cells (Gaudet RG et al. 2015, 2017). Unphosphorylated TIFA is thought to exist as an intrinsic dimer in solution (Huang CC et al. 2012). When T9 is phosphorylated, this is recognized by the FHA domain of other TIFA dimers leading to its oligomerization (Huang CC et al. 2012). Oligomerized TIFA promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 (MAP3K7) and IKK (Ea CK et al. 2004). |
| (summation) | [Reaction:9645535] ALPK1 phosphorylates TIFA [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by TRAF-interacting protein with a forkhead-associated (FHA) do... (9645401)
