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Details on Person Transcription of DDIT3 (CHOP, GADD153) in response to amino acid deficiency

Class:IdBlackBoxEvent:9644926
_displayNameTranscription of DDIT3 (CHOP, GADD153) in response to amino acid deficiency
_doReleaseTRUE
_timestamp2019-11-20 13:57:09
authored[InstanceEdit:9644930] May, Bruce, 2019-04-28
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9644913] May, Bruce, 2019-04-28
edited[InstanceEdit:9644930] May, Bruce, 2019-04-28
inferredFrom
input[EntityWithAccessionedSequence:5642256] DDIT3 gene [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:535556] Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation
[LiteratureReference:9635600] Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels
[LiteratureReference:9635883] Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium
[LiteratureReference:9635932] HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway
[LiteratureReference:9654766] ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation
[LiteratureReference:9654753] Amino acids control mammalian gene transcription: activating transcription factor 2 is essential for the amino acid responsiveness of the CHOP promoter
[LiteratureReference:9635833] Calcium ionophore A23187 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancer-binding protein (C/EBP)-related gene, gadd153. Ca2+ increases transcriptional activity and mRNA stability
[LiteratureReference:9635813] Regulation of the C/EBP-related gene gadd153 by glucose deprivation
modified[InstanceEdit:9650733] May, Bruce, 2019-06-22
[InstanceEdit:9654791] May, Bruce, 2019-07-19
[InstanceEdit:9655882] May, Bruce, 2019-07-27
[InstanceEdit:9658335] May, Bruce, 2019-08-13
[InstanceEdit:9661248] May, Bruce, 2019-09-15
[InstanceEdit:9668176] May, Bruce, 2019-11-20
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTranscription of DDIT3 (CHOP, GADD153) in response to amino acid deficiency
output[EntityWithAccessionedSequence:9650719] DDIT3 mRNA [cytosol] [Homo sapiens]
precedingEvent
regulatedBy[PositiveGeneExpressionRegulation:9644925] Positive gene expression regulation by 'ATF4 dimer:p-T69,T71-ATF2 dimer:DDIT3 gene [nucleoplasm]'
regulationReference[RegulationReference:9644914] Positive gene expression regulation by 'ATF4 dimer:p-T69,T71-ATF2 dimer:DDIT3 gene [nucleoplasm]' Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation
releaseDate2019-12-10
reviewed[InstanceEdit:9661246] Bruhat, Alain, 2019-09-15
[InstanceEdit:9668172] Staschke, Kirk A, 2019-11-20
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9644929] R-HSA-9644926.3
summation[Summation:1791175] The DDIT3 (CHOP) gene is transcribed to yield mRNA and the m...
(hasEvent)[Pathway:9633012] Response of EIF2AK4 (GCN2) to amino acid deficiency [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9650722] Translation of DDIT3 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775498] Update Tracker - [BlackBoxEvent:9644926] Transcription of DDIT3 (CHOP, GADD153) in response to amino acid deficiency - v78:[modifyText]
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