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Details on Person UniProt:Q62645 Grin2d
| Class:Id | ReferenceGeneProduct:96431 |
|---|---|
| _chainChangeLog | signal peptide:1-27 added on Fri February 6 2015;chain:28-1323 added on Fri February 6 2015 |
| _displayName | UniProt:Q62645 Grin2d |
| _timestamp | 2026-02-20 21:42:10 |
| chain | signal peptide:1-27 chain:28-1323 |
| checksum | 40F7D60192579564 |
| comment | FUNCTION Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:21522138, PubMed:23625947, PubMed:7512349). Participates in synaptic plasticity for learning and memory formation (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:21522138, PubMed:23625947, PubMed:7512349). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:23625947, PubMed:7512349, PubMed:9463421).CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)CATALYTIC ACTIVITY K(+)(in) = K(+)(out)SUBUNIT Heterotetramer. Forms heterotetrameric channels composed of two GluN1/zeta subunits (GRIN1), and two identical GluN2/epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) or GluN3 subunits (GRIN3A or GRIN3B) (in vitro) (PubMed:21522138, PubMed:23625947). In vivo, the subunit composition may depend on the expression levels of the different subunits (Probable). Interacts with PDZ domains of PATJ and DLG4 (PubMed:7569905, PubMed:9647694).INTERACTION Expressed in brain, mainly in the subcortical region.DEVELOPMENTAL STAGE Already detected in embryonic stages, peaks at postnatal day 7, and decreases thereafter to adult levels.DOMAIN A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter.SIMILARITY Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily. |
| description | recommendedName: fullName evidence="18"Glutamate receptor ionotropic, NMDA 2D shortName evidence="16"GluN2D alternativeName: fullName evidence="6"Glutamate [NMDA] receptor subunit epsilon-4 alternativeName: N-methyl D-aspartate receptor subtype 2D shortName evidence="2"NMDAR2D shortName: NR2D |
| geneName | Grin2d GluN2D |
| identifier | Q62645 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calcium Cell membrane Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel Magnesium Membrane Methylation Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2455454] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Grin2d |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | NMDE4_RAT Q63381 Q63382 Q63729 Q63730 |
| sequenceLength | 1323 |
| species | [Species:48895] Rattus norvegicus |
| (isoformParent) | [ReferenceIsoform:151157] UniProt:Q62645-2 Grin2d [Rattus norvegicus] [ReferenceIsoform:407731] UniProt:Q62645-1 Grin2d [Rattus norvegicus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9610095] Grin2d [endoplasmic reticulum membrane] [Rattus norvegicus] [EntityWithAccessionedSequence:9614236] Grin2d [plasma membrane] [Rattus norvegicus] [EntityWithAccessionedSequence:9628243] p-Y-Grin2d [plasma membrane] [Rattus norvegicus] |
| (referenceSequence) | [ModifiedResidue:9628247] O4'-phospho-L-tyrosine at unknown position |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q62645 Grin2d (96431)
