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Details on Person UniProt:Q01097 Grin2b
| Class:Id | ReferenceGeneProduct:96426 |
|---|---|
| _chainChangeLog | signal peptide:1-26 added on Fri February 6 2015;chain:27-1482 added on Fri February 6 2015 |
| _displayName | UniProt:Q01097 Grin2b |
| _timestamp | 2026-02-20 21:42:09 |
| chain | signal peptide:1-26 chain:27-1482 |
| checksum | B8C3FA10E9A4B36D |
| comment | FUNCTION Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26912815). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents (PubMed:8789948). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (Probable) (PubMed:1377365, PubMed:20141836, PubMed:7790891). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (By similarity). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage (PubMed:20141836). Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (PubMed:20141836).CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)CATALYTIC ACTIVITY K(+)(in) = K(+)(out)SUBUNIT Heterotetramer. Forms heterotetrameric channels composed of two GluN1/zeta subunits (GRIN1), and two identical GluN2/epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) or GluN3 subunits (GRIN3A or GRIN3B) (in vitro) (PubMed:1377365, PubMed:26912815). Can also form heterotetrameric channels that contain at least two GluN1 subunits and at least two different GluN2 subunits (or a combination of one GluN2 and one GluN3 subunits) (in vitro) (PubMed:12008020, PubMed:14602821). In vivo, the subunit composition may depend on the expression levels of the different subunits (Probable). Found in a complex with GRIN1, GRIN3A and PPP2CB (By similarity). Interacts with MAGI3 (By similarity). Interacts with HIP1 and NETO1 (PubMed:17329427, PubMed:19243221). Interacts with PDZ domains of PATJ, DLG3 and DLG4. Interacts with DAPK1 (PubMed:20141836). Found in a complex with GRIN1 and PRR7. Interacts with PRR7 (By similarity). Interacts with CAMK2A (By similarity). Interacts with ARC; preventing ARC oligomerization (By similarity). Interacts with TMEM25 (PubMed:31424425). Interacts (via the extreme C-terminus) with FRMPD2 (via the second PDZ domain); the interaction is direct and is likely to promote NMDAR-mediated neural signal transmission (PubMed:31196628). GRIN2A binds FRMPD2 with lower affinity than GRIN2B (PubMed:31196628). Interacts with FAM81A; the interaction facilitates condensate formation via liquid-liquid phase separation (PubMed:38452102).INTERACTION Co-localizes with the motor protein KIF17 along microtubules.TISSUE SPECIFICITY Detected in brain (at protein level) (PubMed:8789948). Detected throughout the brain, and in brain stem trigeminal nucleus (PubMed:8789948). Detected in forebrain (PubMed:1377365).DOMAIN The extracellular N-terminal domain (ATD/NTD) endows NMDARs with a unique capacity for allosteric modulation, harboring several binding sites for small molecule ligands that act as subunit-specific allosteric modulators of ion channel activity.DOMAIN A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter.PTM Phosphorylated on tyrosine residues (PubMed:12451687). Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity (PubMed:20141836).DISRUPTION PHENOTYPE Mutant pups are born at the expected Mendelian rate and appear grossly normal, but lack suckling behavior (PubMed:8789948). As a consequence, all die shortly after birth, except when they are fed manually via a soft tube that delivers milk directly into the stomach (PubMed:8789948). While mutant neonate brain structures are grossly normal, the mutant brain stem trigeminal complex lacks the neural repeating units called barrelettes that correspond to whisker-associated nerve fibers (PubMed:8789948). Primary afferent nerve fibers from whiskers fail to show normal clustering in the region where barrelette structures form in wild-type (PubMed:8789948). In contrast, nasolabial motor neurons appear normal (PubMed:8789948). Contrary to wild-type neonates, brain slices from the mutant neonate hippocampus CA1 region lack NMDA receptor-type ion channel activity (PubMed:8789948). Contrary to wild-type pups, prolonged low frequency stimulation of afferent fibers does not induce long-term depression (LTD) in the hippocampus (PubMed:8789948).SIMILARITY Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily. |
| description | recommendedName: fullName evidence="25"Glutamate receptor ionotropic, NMDA 2B shortName evidence="23"GluN2B alternativeName: fullName evidence="22"Glutamate [NMDA] receptor subunit epsilon-2 alternativeName: N-methyl D-aspartate receptor subtype 2B shortName: NMDAR2B shortName evidence="24"NR2B |
| geneName | Grin2b |
| identifier | Q01097 |
| isSequenceChanged | FALSE |
| keyword | Calcium Cell membrane Cell projection Cytoplasm Cytoskeleton Disulfide bond Endosome Glycoprotein Ion channel Ion transport Ligand-gated ion channel Lysosome Magnesium Membrane Metal-binding Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport Zinc |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Grin2b |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | NMDE2_MOUSE Q9DCB2 |
| sequenceLength | 1482 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:3928470] p-Nr2b [plasma membrane] [Mus musculus] [EntityWithAccessionedSequence:3928478] Grin2b [plasma membrane] [Mus musculus] [EntityWithAccessionedSequence:9610361] Grin2b [endoplasmic reticulum membrane] [Mus musculus] [EntityWithAccessionedSequence:9610571] Grin2b [transport vesicle membrane] [Mus musculus] |
| (referenceSequence) | [ModifiedResidue:3928392] O4'-phospho-L-tyrosine at 1292 [ModifiedResidue:3928423] O4'-phospho-L-tyrosine at 1387 [ModifiedResidue:3928428] O4'-phospho-L-tyrosine at 1325 |
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No pathways have been reviewed or authored by UniProt:Q01097 Grin2b (96426)
