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Details on Person Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub

Class:Id	Reaction:9641096
_displayName	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub
_doRelease	TRUE
_timestamp	2020-04-07 10:34:19
authored	[InstanceEdit:9640596] Varusai, Thawfeek, 2019-04-02
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9641087] Varusai, Thawfeek, 2019-04-04
edited	[InstanceEdit:9667290] Varusai, Thawfeek, 2019-11-08
input	[DefinedSet:9641091] Misfolded Proteins [cytosol] [Homo sapiens] [Complex:9641092] Ub:UBE2N:UBE2V1:PRKN [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9641088] Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6
modified	[InstanceEdit:9641107] Varusai, Thawfeek, 2019-04-04 [InstanceEdit:9646697] Varusai, Thawfeek, 2019-05-28 [InstanceEdit:9655715] Varusai, Thawfeek, 2019-07-25 [InstanceEdit:9658415] D'Eustachio, Peter, 2019-08-13 [InstanceEdit:9663819] Varusai, Thawfeek, 2019-10-13 [InstanceEdit:9667360] Varusai, Thawfeek, 2019-11-12 [InstanceEdit:9681506] Varusai, Thawfeek, 2020-04-02 [InstanceEdit:9682019] Varusai, Thawfeek, 2020-04-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub
output	[Complex:9641099] Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9640114] Misfolded proteins translocate from cilium to cytosol [Homo sapiens] [Reaction:9639698] ROS positively regulates misfolding of cilia proteins [Homo sapiens] [Reaction:9641089] Parkin binds Ub:UBE2N:UBE2V1 [Homo sapiens] [Reaction:9640480] E2 enzyme UBE2N:UBE2V1 binds ubiquitin [Homo sapiens]
releaseDate	2019-12-10
reviewed	[InstanceEdit:9682018] Metzakopian, Emmanouil, 2019-05-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9641106] R-HSA-9641096.3
summation	[Summation:9641090] Stress factors damage and misfold cilia proteins, which are ...
(hasEvent)	[Pathway:9646399] Aggrephagy [Homo sapiens]
(precedingEvent)	[Reaction:9641111] Parkin transfers Ub to misfolded proteins [Homo sapiens]
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No pathways have been reviewed or authored by Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (9641096)