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Details on Person Casein kinase 2 (CK2) is a ubiquitously expressed multifunct...
| Class:Id | Summation:9641061 |
|---|---|
| _displayName | Casein kinase 2 (CK2) is a ubiquitously expressed multifunct... |
| _timestamp | 2020-02-14 03:22:08 |
| created | [InstanceEdit:9641068] Shamovsky, Veronica, 2019-04-03 |
| literatureReference | [LiteratureReference:9640161] Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 2 [LiteratureReference:9676413] Protein kinase CK2: structure, regulation and role in cellular decisions of life and death |
| modified | [InstanceEdit:9676414] Shamovsky, Veronica, 2020-02-14 |
| text | Casein kinase 2 (CK2) is a ubiquitously expressed multifunctional serine/threonine kinase that can be activated under inflammatory conditions. CK2 is composed of two catalytic (α or α’) and two regulatory (β) subunits and possesses three isoforms: ααββ, αα’ββ, α’α’ββ (Litchfield DW 2003). Immunofluorescence microscopy and co-immunoprecipitation (CoIP) experiments revealed that the mineralocorticoid receptor (MR or NR3C2) interacted with the catalytic CK2α and regulatory CK2β subunits in NR3C2 (MR)-expressing human embryonic kidney 293 (HEK293) and rat vascular smooth muscle A7r5 cells (Ruhs S et al. 2017). Peptide microarrays using recombinant CK2 and γ-33P-ATP and site-directed mutagenesis experiments identified the highly conserved S459 as a functionally relevant CK2 phosphorylation site of NR3C2 (MR). Thus, CK2 was found to interact and phosphorylate NR3C2 (MR) on S459. CK2-induced phosphorylation of NR3C2 is thought to positively modulate genomic activity of NR3C2 by facilitating NR3C2:DNA interaction (Ruhs S et al. 2017). However, activated NR3C2 may aggravate an existing inflammatory situation via CK2-dependent mechanisms by augmenting NF-kappaB activity leading to the elevated expression of proinflammatory genes (Ruhs S et al. 2017). |
| (summation) | [Reaction:9641070] CK2 phosphorylates NR3C2 [Homo sapiens] |
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