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Details on Person UniProt:Q5SMU7 ORC1
| Class:Id | ReferenceGeneProduct:9640624 |
|---|---|
| _chainChangeLog | chain:1-814 for 9640624 added on Thu May 2 2019 |
| _displayName | UniProt:Q5SMU7 ORC1 |
| _timestamp | 2024-02-26 04:39:47 |
| chain | chain:1-814 |
| checksum | F3E4B562A04F13B0 |
| comment | FUNCTION Essential protein (By similarity). Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity). H3K4me3 effector that positively regulates the transcription of a subset of genes (By similarity). Required for cell proliferation (PubMed:10996242).SUBUNIT Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle and development dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity). Binds unmodified and methylated histone H3 (By similarity).SUBCELLULAR LOCATION Expressed strongly in root tips and shoot apical meristem (SAM), and weakly in young leaves. Not detected in mature leaves.INDUCTION Reduced expression upon sucrose depletion-mediated cell proliferation arrest, and accumulates after sucrose treatment (PubMed:10996242, PubMed:15939553). Induced by gamma irradiation (PubMed:25124817).SIMILARITY Belongs to the ORC1 family. |
| created | [InstanceEdit:9640652] Gupta, Parul, 2019-04-03 |
| description | recommendedName: fullName evidence="13"Origin of replication complex subunit 1 shortName evidence="13"OsORC1 |
| geneName | ORC1 Os06g0187000 LOC_Os06g08790 OsJ_20389 P0470C02.11 |
| identifier | Q5SMU7 |
| isSequenceChanged | FALSE |
| keyword | Activator ATP-binding DNA replication DNA-binding Magnesium Metal-binding Nucleotide-binding Nucleus Reference proteome Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 |
| name | ORC1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ORC1_ORYSJ Q0DDZ5 Q9MB44 |
| sequenceLength | 814 |
| species | [Species:1250427] Oryza sativa subsp. japonica |
| (referenceEntity) | [EntityWithAccessionedSequence:9640675] ORC1 [nucleoplasm] [Oryza sativa] |
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No pathways have been reviewed or authored by UniProt:Q5SMU7 ORC1 (9640624)
