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Details on Person UniProt:Q2R482 MCM2

Class:IdReferenceGeneProduct:9640623
_chainChangeLogchain:1-961 for 9640623 added on Thu May 2 2019
_displayNameUniProt:Q2R482 MCM2
_timestamp2026-02-20 22:01:14
chainchain:1-961
checksumB36AB1D62B8D38BB
commentFUNCTION Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells. Can complement the fission yeast mcm2 mutant.CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT Component of the minichromosome maintenance (MCM) complex, a heterotetramer composed of MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7 (By similarity). Interacts with CSN5 (PubMed:18755073).SUBCELLULAR LOCATION Widely expressed, with higher expression in developing tissues.SIMILARITY Belongs to the MCM family.
created[InstanceEdit:9640652] Gupta, Parul, 2019-04-03
descriptionrecommendedName: fullName evidence="8"DNA replication licensing factor MCM2 ecNumber evidence="8"3.6.4.12 alternativeName: fullName evidence="7"Minichromosome maintenance protein 2 shortName evidence="7"OsMCM2
geneNameMCM2
Os11g0484300
LOC_Os11g29380
OsJ_33907
identifierQ2R482
isSequenceChangedFALSE
keywordATP-binding
Cell cycle
DNA replication
DNA-binding
Helicase
Hydrolase
Metal-binding
Nucleotide-binding
Nucleus
Reference proteome
Zinc
Zinc-finger
modified[InstanceEdit:9645038] Weiser, JD
[InstanceEdit:9657908] Weiser, JD
[InstanceEdit:9676415] Weiser, JD
[InstanceEdit:9750299] Weiser, JD
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
nameMCM2
referenceDatabase[ReferenceDatabase:2] UniProt
secondaryIdentifierMCM2_ORYSJ
A0A0N7KSX8
sequenceLength961
species[Species:1250427] Oryza sativa subsp. japonica
(referenceEntity)[EntityWithAccessionedSequence:9640753] MCM2 [nucleoplasm] [Oryza sativa]
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No pathways have been reviewed or authored by UniProt:Q2R482 MCM2 (9640623)