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Details on Person RRAGA,B hydrolyzes GTP

Class:Id	Reaction:9640195
_displayName	RRAGA,B hydrolyzes GTP
_doRelease	TRUE
_timestamp	2019-08-15 15:43:43
authored	[InstanceEdit:9640170] May, Bruce, 2019-03-11
catalystActivity	[CatalystActivity:9645593] GTPase activity of v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane]
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:9640178] May, Bruce, 2019-03-23
edited	[InstanceEdit:9640170] May, Bruce, 2019-03-11
input	[Complex:9646467] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9640185] Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases [LiteratureReference:9646572] A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1 [LiteratureReference:5653943] Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases [LiteratureReference:9639282] Sestrin2 is a leucine sensor for the mTORC1 pathway [LiteratureReference:9639285] Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway [LiteratureReference:9646216] Sestrin2 inhibits mTORC1 through modulation of GATOR complexes [LiteratureReference:9646208] Sestrins inhibit mTORC1 kinase activation through the GATOR complex [LiteratureReference:9646214] The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1 [LiteratureReference:9647602] Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling [LiteratureReference:9646209] Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway [LiteratureReference:9646210] Mechanism of arginine sensing by CASTOR1 upstream of mTORC1 [LiteratureReference:9646213] Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling [LiteratureReference:9646218] The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway [LiteratureReference:9640286] SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
modified	[InstanceEdit:9640281] May, Bruce, 2019-03-25 [InstanceEdit:9645591] May, Bruce, 2019-05-13 [InstanceEdit:9645605] May, Bruce, 2019-05-13 [InstanceEdit:9646273] May, Bruce, 2019-05-20 [InstanceEdit:9646478] May, Bruce, 2019-05-24 [InstanceEdit:9646574] May, Bruce, 2019-05-25 [InstanceEdit:9647611] May, Bruce, 2019-06-02 [InstanceEdit:9647734] May, Bruce, 2019-06-03 [InstanceEdit:9647740] May, Bruce, 2019-06-03 [InstanceEdit:9652209] May, Bruce, 2019-06-28 [InstanceEdit:9657657] May, Bruce, 2019-08-08 [InstanceEdit:9657681] May, Bruce, 2019-08-08 [InstanceEdit:9658508] May, Bruce, 2019-08-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RRAGA,B hydrolyzes GTP
output	[SimpleEntity:29372] Pi [cytosol] [Complex:9646465] v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] [Homo sapiens]
regulatedBy	[PositiveRegulation:9645596] Positive regulation by 'KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane]' [PositiveRegulation:9645594] Positive regulation by 'KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2 [lysosomal membrane]' [NegativeRegulation:9645590] Negative regulation by 'KICSTOR:GATOR1:GATOR2 [lysosomal membrane]' [PositiveRegulation:9645604] Positive regulation by 'KICSTOR:GATOR1:BMT2 [lysosomal membrane]' [PositiveRegulation:9657642] Positive regulation by 'KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane]'
regulationReference	[RegulationReference:9647731] Positive regulation by 'KICSTOR:GATOR1:BMT2 [lysosomal membrane]' SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway [RegulationReference:9647727] Positive regulation by 'KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1,2 [lysosomal membrane]' Mechanism of arginine sensing by CASTOR1 upstream of mTORC1 [RegulationReference:9647728] Positive regulation by 'KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane]' Sestrin2 inhibits mTORC1 through modulation of GATOR complexes [RegulationReference:9647730] Negative regulation by 'KICSTOR:GATOR1:GATOR2 [lysosomal membrane]' A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1 [RegulationReference:9657640] Positive regulation by 'KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane]' Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
releaseDate	2019-09-10
reviewed	[InstanceEdit:9657680] Condon, Kendall J, Sabatini, David M, 2019-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9640217] R-HSA-9640195.2
summation	[Summation:9647606] The GTPase activity of RRAGA,B hydrolyzes GTP to GDP (Bar-Pe...
(hasEvent)	[Pathway:9639288] Amino acids regulate mTORC1 [Homo sapiens]
(precedingEvent)	[Reaction:9645595] RRAGC,D exchanges GDP for GTP [Homo sapiens]
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No pathways have been reviewed or authored by RRAGA,B hydrolyzes GTP (9640195)