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Details on Person RRAGA,B exchanges GDP for GTP

Class:Id	Reaction:9640167
_displayName	RRAGA,B exchanges GDP for GTP
_doRelease	TRUE
_timestamp	2019-08-08 18:49:49
authored	[InstanceEdit:9640182] May, Bruce, 2019-03-23
catalystActivity	[CatalystActivity:9647604] guanyl-nucleotide exchange factor activity of v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane]
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:9640178] May, Bruce, 2019-03-23
edited	[InstanceEdit:9640218] May, Bruce, 2019-03-23
input	[Complex:9640192] v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9640249] SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling [LiteratureReference:9640284] Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms [LiteratureReference:9646247] Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability [LiteratureReference:5655439] Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
modified	[InstanceEdit:9640281] May, Bruce, 2019-03-25 [InstanceEdit:9646229] May, Bruce, 2019-05-20 [InstanceEdit:9646273] May, Bruce, 2019-05-20 [InstanceEdit:9646574] May, Bruce, 2019-05-25 [InstanceEdit:9647593] May, Bruce, 2019-06-01 [InstanceEdit:9647611] May, Bruce, 2019-06-02 [InstanceEdit:9647612] May, Bruce, 2019-06-02 [InstanceEdit:9647734] May, Bruce, 2019-06-03 [InstanceEdit:9657681] May, Bruce, 2019-08-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RRAGA,B exchanges GDP for GTP
output	[Complex:9639283] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:9640175] v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine [Homo sapiens] [Reaction:9639286] RRAGC,D exchanges GTP for GDP [Homo sapiens]
regulatedBy	[NegativeRegulation:9640258] Negative regulation by 'SH3BP4 [cytosol]'
regulationReference	[RegulationReference:9647721] Negative regulation by 'SH3BP4 [cytosol]' SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling
releaseDate	2019-09-10
reviewed	[InstanceEdit:9657680] Condon, Kendall J, Sabatini, David M, 2019-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9640196] R-HSA-9640167.2
summation	[Summation:9640225] Upon binding L-arginine, SLC38A9 acts as a guanyl nucleotide...
(hasEvent)	[Pathway:9639288] Amino acids regulate mTORC1 [Homo sapiens]
(precedingEvent)	[Reaction:9640168] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine [Homo sapiens]
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No pathways have been reviewed or authored by RRAGA,B exchanges GDP for GTP (9640167)