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Details on Person Based on studies in mice, in the absence of neuronal activit...
| Class:Id | Summation:9640073 |
|---|---|
| _displayName | Based on studies in mice, in the absence of neuronal activit... |
| _timestamp | 2022-04-05 13:30:28 |
| created | [InstanceEdit:9640075] Orlic-Milacic, Marija, 2019-03-20 |
| literatureReference | [LiteratureReference:9639550] DREAM controls the on/off switch of specific activity-dependent transcription pathways [LiteratureReference:9640045] DREAM is a Ca2+-regulated transcriptional repressor [LiteratureReference:9640044] Mg2+ and Ca2+ differentially regulate DNA binding and dimerization of DREAM |
| modified | [InstanceEdit:9770515] Orlic-Milacic, Marija, 2022-04-05 |
| text | Based on studies in mice, in the absence of neuronal activity-induced calcium influx, KCNIP3 (DREAM) binds to the promoter of the NPAS4 gene and represses NPAS4 transcription (Mellström et al. 2014). KCNIP3 binds to target promoters as a homotetramer (Carrion et al. 1999). Magnesium is required for stable binding of KCNIP3 homotetramers to target DNA. KCNIP3 possesses one high-affinity, constitutive, Mg2+ binding site and two low-affinity Mg2+ sites (Osawa et al. 2005). |
| (summation) | [Reaction:9640060] KCNIP3 binds NPAS4 gene promoter [Homo sapiens] |
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No pathways have been reviewed or authored by Based on studies in mice, in the absence of neuronal activit... (9640073)
