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Details on Person UniProt:Q8IXH7 NELFCD
| Class:Id | ReferenceGeneProduct:96395 |
|---|---|
| _chainChangeLog | chain:1-590 added on Sat February 7 2015 |
| _displayName | UniProt:Q8IXH7 NELFCD |
| _timestamp | 2024-11-03 20:02:05 |
| chain | chain:1-590 |
| checksum | 425437DC46DAF953 |
| comment | FUNCTION Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401).FUNCTION (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.SUBUNIT The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE; NELFA and NELFCD form a stable subcomplex that binds primarily through NELFCD to the N-terminus of NELFB (PubMed:12612062, PubMed:27282391). Binds RNA which may help to stabilize the NELF complex on nucleic acid (PubMed:27282391). In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and structure-dependent manner (PubMed:27282391). Interacts with ARAF (PubMed:11952167). Interacts with PCF11 (PubMed:23884411). Interacts with KAT8 (By similarity).INTERACTION Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas.MISCELLANEOUS Produced by alternative initiation at Met-10 of isoform NELF-C.SIMILARITY Belongs to the NELF-D family. |
| description | recommendedName: Negative elongation factor C/D shortName: NELF-C/D alternativeName: TH1-like protein |
| geneName | NELFCD NELFD TH1 TH1L HSPC130 |
| identifier | Q8IXH7 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative initiation Alternative splicing Direct protein sequencing Nucleus Proteomics identification Reference proteome Repressor RNA-binding Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NELFCD |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001921] ENSEMBL:ENSG00000101158 NELFCD [Homo sapiens] |
| secondaryIdentifier | NELFD_HUMAN B4DE06 Q9BYL2 Q9H405 Q9H888 Q9H8T3 Q9NVX5 Q9P029 Q9UGN1 Q9UGN2 Q9UGN3 |
| sequenceLength | 590 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:151129] UniProt:Q8IXH7-3 NELFCD [Homo sapiens] [ReferenceIsoform:239193] UniProt:Q8IXH7-4 NELFCD [Homo sapiens] [ReferenceIsoform:410884] UniProt:Q8IXH7-1 NELFCD [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:112428] NELFCD [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8IXH7 NELFCD (96395)
