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Details on Person The tripartite efflux system MacA:MacB:TolC in enterobacteri...
| Class:Id | Summation:9639479 |
|---|---|
| _displayName | The tripartite efflux system MacA:MacB:TolC in enterobacteri... |
| _timestamp | 2024-07-04 08:27:41 |
| created | [InstanceEdit:9639460] Pardo, Agustin, 2019-03-12 |
| modified | [InstanceEdit:9911196] Stephan, Ralf, 2024-05-27 [InstanceEdit:9915279] Stephan, Ralf, 2024-07-04 |
| text | The tripartite efflux system MacA:MacB:TolC in enterobacteria confers resistance to macrolides, for example azithromycin. The system consists of a porin TolC trimer in the outer membrane, the ATPase inner membrane pump MacB, and a binding protein MacA that increases the pump's capacity and affinity to macrolides. The TolC trimer projects an α-helical tunnel across the periplasm, ending at the inner membrane transporter. The transport consists of two reactions, both catalyzed by the periplasm-spanning complex. In the first reaction catalyzed by the MacB subunit, one molecule of ATP is spent for the export of azithromycin out of the cytosol (Kobayashi et al. 2001; Pei et al., 2011; reviewed by Alav et al., 2021). |
| (summation) | [Reaction:9639466] macA:macB:tolC transports azithromycin from the cytosol to the periplasm [Escherichia coli] [Reaction:9911514] MacA:MacB:TolC transports azithromycin from the cytosol to the periplasm [Homo sapiens] |
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No pathways have been reviewed or authored by The tripartite efflux system MacA:MacB:TolC in enterobacteri... (9639479)
