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Details on Person macA:macB:tolC transports azithromycin from the cytosol to the periplasm

Class:Id	Reaction:9639466
_displayName	macA:macB:tolC transports azithromycin from the cytosol to the periplasm
_doRelease	FALSE
_timestamp	2024-05-28 08:25:57
authored	[InstanceEdit:9638337] Stephan, Ralf, 2019-02-21
catalystActivity	[CatalystActivity:9911301] ABC-type xenobiotic transporter activity of MacA:MacB:TolC [cell outer membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:1222638] periplasmic space
created	[InstanceEdit:9639460] Pardo, Agustin, 2019-03-12
input	[ChemicalDrug:39493] azithromycin [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9639429] Novel macrolide-specific ABC-type efflux transporter in Escherichia coli [LiteratureReference:9911186] Structures of sequential open states in a symmetrical opening transition of the TolC exit duct [LiteratureReference:9911195] Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria
modified	[InstanceEdit:9640155] Pardo, Agustin, 2019-03-22 [InstanceEdit:9640500] Jassal, Bijay, 2019-03-29 [InstanceEdit:9911196] Stephan, Ralf, 2024-05-27 [InstanceEdit:9911302] Stephan, Ralf, 2024-05-28
name	macA:macB:tolC transports azithromycin from the cytosol to the periplasm
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [ChemicalDrug:9911188] azithromycin [periplasmic space]
species	[Species:159879] Escherichia coli
stableIdentifier	[StableIdentifier:9640557] R-ECO-9639466.1
structureModified	[InstanceEdit:9911196] Stephan, Ralf, 2024-05-27
summation	[Summation:9639479] The tripartite efflux system MacA:MacB:TolC in enterobacteri...
(precedingEvent)	[Reaction:9911199] macA:macB:tolC transports azithromycin from the periplasm to the extracellular region [Escherichia coli]
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No pathways have been reviewed or authored by macA:macB:tolC transports azithromycin from the cytosol to the periplasm (9639466)