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Details on Person acrA:acrB:tolC transports azithromycin from the cytosol to the periplasm

Class:Id	Reaction:9639434
_displayName	acrA:acrB:tolC transports azithromycin from the cytosol to the periplasm
_doRelease	FALSE
_timestamp	2024-05-28 08:25:40
authored	[InstanceEdit:9638337] Stephan, Ralf, 2019-02-21
catalystActivity	[CatalystActivity:9639457] xenobiotic transmembrane transporter activity of AcrA:AcrB:TolC [cell outer membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:1222638] periplasmic space
created	[InstanceEdit:9639460] Pardo, Agustin, 2019-03-12
input	[ChemicalDrug:39493] azithromycin [cytosol] [SimpleEntity:8858135] H+ [periplasmic space]
isChimeric	FALSE
literatureReference	[LiteratureReference:9639485] Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance [LiteratureReference:9639435] AcrA is a highly asymmetric protein capable of spanning the periplasm [LiteratureReference:9911303] RND transporters in the living world [LiteratureReference:9911195] Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria
modified	[InstanceEdit:9640155] Pardo, Agustin, 2019-03-22 [InstanceEdit:9911302] Stephan, Ralf, 2024-05-28
name	acrA:acrB:tolC transports azithromycin from the cytosol to the periplasm
output	[SimpleEntity:70106] H+ [cytosol] [ChemicalDrug:9911188] azithromycin [periplasmic space]
species	[Species:159879] Escherichia coli
stableIdentifier	[StableIdentifier:9639508] R-ECO-9639434.1
structureModified	[InstanceEdit:9911302] Stephan, Ralf, 2024-05-28
summation	[Summation:9639497] The tripartite efflux system acrA:acrB:tolC is the predomina...
(precedingEvent)	[Reaction:9911305] acrA:acrB:tolC transports azithromycin from the periplasm to the extracellular region [Escherichia coli]
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No pathways have been reviewed or authored by acrA:acrB:tolC transports azithromycin from the cytosol to the periplasm (9639434)