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Details on Person RRAGC,D exchanges GTP for GDP

Class:Id	Reaction:9639286
_displayName	RRAGC,D exchanges GTP for GDP
_doRelease	TRUE
_timestamp	2019-08-08 18:50:00
authored	[InstanceEdit:9638279] May, Bruce, 2019-03-04
catalystActivity	[CatalystActivity:9640183] guanyl-nucleotide exchange factor activity of v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane]
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:9639278] May, Bruce, 2019-03-09
edited	[InstanceEdit:9638279] May, Bruce, 2019-03-04
input	[Complex:9640174] v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9640284] Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms
modified	[InstanceEdit:9640218] May, Bruce, 2019-03-23 [InstanceEdit:9640281] May, Bruce, 2019-03-25 [InstanceEdit:9640399] May, Bruce, 2019-03-26 [InstanceEdit:9645591] May, Bruce, 2019-05-13 [InstanceEdit:9646273] May, Bruce, 2019-05-20 [InstanceEdit:9657681] May, Bruce, 2019-08-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RRAGC,D exchanges GTP for GDP
output	[Complex:9640184] v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
precedingEvent	[BlackBoxEvent:9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 [Homo sapiens]
releaseDate	2019-09-10
reviewed	[InstanceEdit:9657680] Condon, Kendall J, Sabatini, David M, 2019-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9639297] R-HSA-9639286.2
summation	[Summation:9640245] The Ragulator complex acts as an unconventional guanyl nucle...
(hasEvent)	[Pathway:9639288] Amino acids regulate mTORC1 [Homo sapiens]
(precedingEvent)	[Reaction:9640175] v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine [Homo sapiens]
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No pathways have been reviewed or authored by RRAGC,D exchanges GTP for GDP (9639286)