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Details on Person Sestrin2 is a leucine sensor for the mTORC1 pathway
| Class:Id | LiteratureReference:9639282 |
| _displayName | Sestrin2 is a leucine sensor for the mTORC1 pathway |
| _timestamp | 2019-03-09 03:35:54 |
| author | [Person:8952712] Wolfson, Rachel L [Person:5696369] Chantranupong, Lynne [Person:9639279] Saxton, Robert A [Person:8952728] Shen, Kuang [Person:9639293] Scaria, Sonia M [Person:5696372] Cantor, Jason R [Person:5083667] Sabatini, David M |
| created | [InstanceEdit:9639278] May, Bruce, 2019-03-09 |
| journal | Science |
| pages | 43-8 |
| pubMedIdentifier | 26449471 |
| title | Sestrin2 is a leucine sensor for the mTORC1 pathway |
| volume | 351 |
| year | 2016 |
| (literatureReference) | [Complex:9639275] KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] [Homo sapiens] [Complex:9639284] GATOR2:SESN1,2 [lysosomal membrane] [Homo sapiens] [RegulationReference:9647728] Positive regulation by 'KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane]' Sestrin2 inhibits mTORC1 through modulation of GATOR complexes [BlackBoxEvent:9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 [Homo sapiens] [Pathway:9639288] Amino acids regulate mTORC1 [Homo sapiens] [Reaction:9640195] RRAGA,B hydrolyzes GTP [Homo sapiens] |
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