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Details on Person Sestrin2 is a leucine sensor for the mTORC1 pathway

Class:IdLiteratureReference:9639282
_displayNameSestrin2 is a leucine sensor for the mTORC1 pathway
_timestamp2019-03-09 03:35:54
author[Person:8952712] Wolfson, Rachel L
[Person:5696369] Chantranupong, Lynne
[Person:9639279] Saxton, Robert A
[Person:8952728] Shen, Kuang
[Person:9639293] Scaria, Sonia M
[Person:5696372] Cantor, Jason R
[Person:5083667] Sabatini, David M
created[InstanceEdit:9639278] May, Bruce, 2019-03-09
journalScience
pages43-8
pubMedIdentifier26449471
titleSestrin2 is a leucine sensor for the mTORC1 pathway
volume351
year2016
(literatureReference)[Complex:9639275] KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] [Homo sapiens]
[Complex:9639284] GATOR2:SESN1,2 [lysosomal membrane] [Homo sapiens]
[RegulationReference:9647728] Positive regulation by 'KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane]' Sestrin2 inhibits mTORC1 through modulation of GATOR complexes
[BlackBoxEvent:9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 [Homo sapiens]
[Pathway:9639288] Amino acids regulate mTORC1 [Homo sapiens]
[Reaction:9640195] RRAGA,B hydrolyzes GTP [Homo sapiens]
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