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Details on Person UniProt:P02919 mrcB
| Class:Id | ReferenceGeneProduct:9638855 |
|---|---|
| _chainChangeLog | chain:1-844 for 9638855 added on Thu May 2 2019 |
| _displayName | UniProt:P02919 mrcB |
| _timestamp | 2025-02-21 19:51:58 |
| chain | chain:1-844 |
| checksum | CED0A19FAC73961E |
| comment | FUNCTION Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).CATALYTIC ACTIVITY [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans,octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)CATALYTIC ACTIVITY Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.PATHWAY Cell wall biogenesis; peptidoglycan biosynthesis.SUBUNIT Forms a trimeric complex with MipA and MltA. Has also been shown to exist as monomer or homodimer; homodimer of Alpha and Gamma isozymes can be found. Interacts with UvrA, FtsL and FtsN.INTERACTION The UvrB domain 2 homolog region (UB2H domain) is important for interaction with MltA.MISCELLANEOUS A third isozyme, Beta, lacking the first 25 N-terminal amino acids of the isoform Alpha and a fourth isozyme, Delta, have been found, but seem to result from the artifactual degradation of the isoform Alpha and isoform Gamma respectively.SIMILARITY In the N-terminal section; belongs to the glycosyltransferase 51 family.SIMILARITY In the C-terminal section; belongs to the transpeptidase family.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:9638864] Jassal, Bijay, 2019-03-06 |
| description | recommendedName: Penicillin-binding protein 1B shortName: PBP-1b shortName: PBP1b alternativeName: Murein polymerase domain recommendedName: Penicillin-insensitive transglycosylase ecNumber evidence="4 5"2.4.99.28 alternativeName: Peptidoglycan TGase alternativeName: Peptidoglycan glycosyltransferase /domain domain recommendedName: Penicillin-sensitive transpeptidase ecNumber evidence="5"3.4.16.4 alternativeName: DD-transpeptidase /domain |
| geneName | mrcB pbpF ponB b0149 JW0145 |
| identifier | P02919 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative initiation Antibiotic resistance Carboxypeptidase Cell inner membrane Cell membrane Cell shape Cell wall biogenesis/degradation Direct protein sequencing Glycosyltransferase Hydrolase Membrane Multifunctional enzyme Peptidoglycan synthesis Protease Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | mrcB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PBPB_ECOLI A0A7H2C765 P75664 |
| sequenceLength | 844 |
| species | [Species:159879] Escherichia coli |
| (isoformParent) | [ReferenceIsoform:9645054] UniProt:P02919-1 mrcB [Escherichia coli] [ReferenceIsoform:9645055] UniProt:P02919-2 mrcB [Escherichia coli] |
| (referenceEntity) | [EntityWithAccessionedSequence:9638844] MrcB [cytosol] [Escherichia coli] |
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No pathways have been reviewed or authored by UniProt:P02919 mrcB (9638855)
