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Details on Person UniProt:Q9F663 KPC-2

Class:IdReferenceGeneProduct:9638727
_chainChangeLogsignal peptide:1-24 for 9638727 added on Fri May 3 2019;chain:25-293 for 9638727 added on Fri May 3 2019
_displayNameUniProt:Q9F663 KPC-2
_timestamp2025-02-21 20:18:52
chainsignal peptide:1-24
chain:25-293
checksum13EB2FC28005EE5F
commentFUNCTION Class A beta-lactamase which confers resistance to the beta-lactam antibiotics, including penicillins, cephalosporins and carbapenems (PubMed:11257029). Acts via hydrolysis of the beta-lactam ring (PubMed:11257029, PubMed:33257320). Has penicillin-, cephalosporin- and carbapenem-hydrolyzing activities (PubMed:11257029, PubMed:33257320).CATALYTIC ACTIVITY a beta-lactam + H2O = a substituted beta-amino acidACTIVITY REGULATION Not inhibited by EDTA, inhibited by clavulanic acid and tazobactam (PubMed:11257029). Inhibited by cyclic boronates, including vaborbactam and bicyclic analogs of taniborbactam (PubMed:33479650).BIOPHYSICOCHEMICAL PROPERTIES kcat is 32 sec(-1) with benzylpenicillin as substrate (at pH 7.0 and 25 degrees Celsius) (PubMed:11257029). kcat is 340 sec(-1) with cephaloridine as substrate (at pH 7.0 and 25 degrees Celsius) (PubMed:11257029). kcat is 75 sec(-1) with cephalothin as substrate (at pH 7.0 and 25 degrees Celsius) (PubMed:11257029). kcat is 78 sec(-1) with nitrocefin as substrate (at pH 7.0 and 25 degrees Celsius) (PubMed:11257029). kcat is 610 sec(-1) with nitrocefin as substrate (at pH 7.5 and 25 degrees Celsius) (PubMed:33257320). kcat is 14 sec(-1) with cefotaxime as substrate (at pH 7.0 and 25 degrees Celsius) (PubMed:11257029). kcat is 76 sec(-1) with cefotaxime as substrate (at pH 7.5 and 25 degrees Celsius) (PubMed:33257320). kcat is 0.26 sec(-1) with cefoxitin as substrate (at pH 7.0 and 25 degrees Celsius) (PubMed:11257029). kcat is 0.1 sec(-1) with ceftazidime as substrate (at pH 7.0 and 25 degrees Celsius) (PubMed:11257029). kcat is 1.9 sec(-1) with ceftazidime as substrate (at pH 7.5 and 25 degrees Celsius) (PubMed:33257320). kcat is 110 sec(-1) with ampicillin as substrate (at pH 7.0 and 25 degrees Celsius) (PubMed:11257029). kcat is 25 sec(-1) with cloxacillin as substrate (at pH 7.0 and 25 degrees Celsius) (PubMed:11257029). kcat is 24 sec(-1) with piperacillin as substrate (at pH 7.0 and 25 degrees Celsius) (PubMed:11257029). kcat is 12.4 sec(-1) with imipenem as substrate (at pH 7.0 and 25 degrees Celsius) (PubMed:11257029). kcat is 3.0 sec(-1) with meropenem as substrate (at pH 7.0 and 25 degrees Celsius) (PubMed:11257029). kcat is 20 sec(-1) with aztreonam as substrate (at pH 7.0 and 25 degrees Celsius) (PubMed:11257029).MISCELLANEOUS Initially two different KPC beta-lactamases were identified from two different Klebsiella (KPC-1 and KPC-2); they were later shown to be identical.MISCELLANEOUS The class A beta-lactamase family has a specific amino-acid numbering system, sometimes called Ambler or ABL numbering and often misspelt as Amber. A multiple sequence alignment was used to derive a consensus sequence and then the consensus was numbered taking into account insertions and deletions. This allows use of identical numbers, e.g. for active site residues, despite differences in protein length. UniProt always uses natural numbering of residues, hence there appear to be differences in numbering between this entry and some papers.SIMILARITY Belongs to the class-A beta-lactamase family.
created[InstanceEdit:9638735] Pardo, Agustin, 2019-03-05
descriptionrecommendedName: fullName evidence="13"Carbapenem-hydrolyzing beta-lactamase KPC-2 ecNumber evidence="3 5"3.5.2.6 alternativeName: fullName evidence="9"Carbapenem-hydrolyzing beta-lactamase KPC-1
geneNameKPC-2
bla
kpc
KPC-1
kpc1
identifierQ9F663
isSequenceChangedFALSE
keyword3D-structure
Antibiotic resistance
Hydrolase
Plasmid
Signal
modified[InstanceEdit:9645058] Weiser, JD
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
nameKPC-2
referenceDatabase[ReferenceDatabase:2] UniProt
secondaryIdentifierBLKPC_KLEPN
sequenceLength293
species[Species:9638647] Klebsiella pneumoniae
(referenceEntity)[EntityWithAccessionedSequence:9638741] KPC-2 [cytosol] [Klebsiella pneumoniae]
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