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Details on Person FimH binds D-mannose moiety on host cell

Class:Id	Reaction:9638571
_displayName	FimH binds D-mannose moiety on host cell
_doRelease	TRUE
_timestamp	2025-05-21 07:41:49
authored	[InstanceEdit:9637715] Stephan, Ralf, 2019-02-19
compartment	[Compartment:20798] cell outer membrane [Compartment:876] plasma membrane
created	[InstanceEdit:9638547] Pardo, Agustin, 2019-03-05
disease	[Disease:3134792] bacterial infectious disease
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
input	[EntityWithAccessionedSequence:9638613] FimH [cell outer membrane] [Escherichia coli] [DefinedSet:9931995] D-mannose bearing glycoproteins [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9915005] Gillespie, Marc E, 2024-07-02 [InstanceEdit:9917579] Gillespie, Marc E, 2024-08-08 [InstanceEdit:9937184] Matthews, Lisa, 2025-01-30
isChimeric	FALSE
literatureReference	[LiteratureReference:9638601] In vitro binding of type 1-fimbriated Escherichia coli to uroplakins Ia and Ib: relation to urinary tract infections [LiteratureReference:9638597] Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH binding [LiteratureReference:9638654] Direct evidence that the FimH protein is the mannose-specific adhesin of Escherichia coli type 1 fimbriae [LiteratureReference:9932002] Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract [LiteratureReference:9932003] Role of D-Mannose in the Prevention of Recurrent Uncomplicated Cystitis: State of the Art and Future Perspectives [LiteratureReference:9638614] Catch-bond mechanism of the bacterial adhesin FimH
modified	[InstanceEdit:9640155] Pardo, Agustin, 2019-03-22 [InstanceEdit:9915006] Stephan, Ralf, 2024-07-02 [InstanceEdit:9915160] Stephan, Ralf, 2024-07-03 [InstanceEdit:9917580] Stephan, Ralf, 2024-08-08 [InstanceEdit:9931098] Stephan, Ralf, 2024-12-10 [InstanceEdit:9931991] Stephan, Ralf, 2024-12-15 [InstanceEdit:9933047] Stephan, Ralf, 2024-12-23 [InstanceEdit:9937183] Stephan, Ralf, 2025-01-30 [InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	FimH binds D-mannose moiety on host cell
output	[Complex:9932000] FimH:D-mannose bearing glycoproteins [plasma membrane] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821380] one star
regulatedBy	[NegativeRegulation:9931987] Negative regulation by 'D-mannose [extracellular region]'
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9638667] R-HSA-9638571.1
structureModified	[InstanceEdit:9931991] Stephan, Ralf, 2024-12-15
summation	[Summation:9931988] FimH, as part of type I pili in pathogenic E.coli strains, b...
(hasEvent)	[Pathway:9638630] Attachment of bacteria to epithelial cells [Homo sapiens]
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