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Details on Person UniProt:P02929 tonB
| Class:Id | ReferenceGeneProduct:9638541 |
|---|---|
| _chainChangeLog | chain:1-239 for 9638541 added on Thu May 2 2019 |
| _displayName | UniProt:P02929 tonB |
| _timestamp | 2023-11-03 17:09:20 |
| chain | chain:1-239 |
| checksum | 3B59F39D791AE815 |
| comment | FUNCTION Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy-dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847).SUBUNIT Homodimer. Forms a complex with the accessory proteins ExbB and ExbD.INTERACTION 2-fold by hydroxyurea treatment.DISRUPTION PHENOTYPE Cells missing tonB survive hydroxyurea treatment better than wild-type; further disruption of mazE-mazF and relE-relB yields even better survival (PubMed:20005847).SIMILARITY Belongs to the TonB family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:9638539] Pardo, Agustin, 2019-03-05 |
| description | recommendedName: Protein TonB |
| geneName | tonB exbA b1252 JW5195 |
| identifier | P02929 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Bacteriocin transport Cell inner membrane Cell membrane Membrane Protein transport Reference proteome Repeat Signal-anchor Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | tonB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TONB_ECOLI P76831 P94719 P94722 P94726 P94728 P94732 P94736 P94739 P97239 |
| sequenceLength | 239 |
| species | [Species:159879] Escherichia coli |
| (referenceEntity) | [EntityWithAccessionedSequence:9638538] tonB [plasma membrane] [Escherichia coli] [EntityWithAccessionedSequence:9911680] TonB [plasma membrane] [Escherichia coli] |
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No pathways have been reviewed or authored by UniProt:P02929 tonB (9638541)
