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Details on Person Under acidic or anaerobic conditions iron may be prevalent i...
| Class:Id | Summation:9638511 |
|---|---|
| _displayName | Under acidic or anaerobic conditions iron may be prevalent i... |
| _timestamp | 2024-07-04 08:27:44 |
| created | [InstanceEdit:9638466] Pardo, Agustin, 2019-03-05 |
| modified | [InstanceEdit:9911686] Stephan, Ralf, 2024-06-04 [InstanceEdit:9915003] Stephan, Ralf, 2024-07-01 [InstanceEdit:9915279] Stephan, Ralf, 2024-07-04 |
| text | Under acidic or anaerobic conditions iron may be prevalent in the reduced ferrous form (Fe2+). The import of Fe2+ enhances pathogenic bacteria virulence (Stojiljkovic et al. 1993). Ferrous iron is thought to diffuse freely through outer membrane porins. Transport through the plasma membrane is mediated by the FeoAB system which consists of a large transmembrane GTPase protein, FeoB, and a small accessory cytoplasmic protein, FeoA. GTP hydrolysis delivers the energy needed for transport (Kammler et al. 1993, Marlovits et al., 2002; Lau et al. 2013, Lau et al. 2016). Biochemical analyses demonstrated that the GTPase activity of FeoB is activated by K+, which leads to a 20-fold acceleration in its hydrolysis rate (Ash et al. 2010). |
| (summation) | [Reaction:9638485] feoAB transports Fe2+ from periplasmic space to the cytosol [Escherichia coli] [Reaction:9911596] FeoAB transports Fe2+ from periplasmic space to the cytosol [Homo sapiens] |
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No pathways have been reviewed or authored by Under acidic or anaerobic conditions iron may be prevalent i... (9638511)
