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Details on Person HEXB cleaves the terminal GalNAc from DS

Class:Id	Reaction:9638075
_displayName	HEXB cleaves the terminal GalNAc from DS
_doRelease	TRUE
_timestamp	2025-03-07 10:21:27
authored	[InstanceEdit:2105013] Jassal, B, 2012-02-09
catalystActivity	[CatalystActivity:9638074] beta-N-acetylhexosaminidase activity of bHEXB [lysosomal lumen]
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:9638080] Jassal, Bijay, 2019-02-25
edited	[InstanceEdit:2105013] Jassal, B, 2012-02-09
goBiologicalProcess	[GO_BiologicalProcess:21608] dermatan sulfate proteoglycan catabolic process
input	[SimpleEntity:1605715] H2O [lysosomal lumen] [SimpleEntity:2065269] ChEBI:63516 chain [lysosomal lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:1605770] Oligosaccharide structure and amino acid sequence of the major glycopeptides of mature human beta-hexosaminidase
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9941068] Stephan, Ralf, 2025-03-07
name	HEXB cleaves the terminal GalNAc from DS
output	[SimpleEntity:1605658] GalNAc [lysosomal lumen] [SimpleEntity:2105025] IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl [lysosomal lumen]
precedingEvent	[Reaction:1793182] IDS hydrolyses dermatan sulfate (Chebi:63517 chain) [Homo sapiens] [Reaction:1606789] ARSB hydrolyses DS [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9638082] R-HSA-9638075.3
summation	[Summation:1638038] Beta-hexosaminidase (HEX) cleaves the terminal N-acetyl gluc...
(hasEvent)	[Pathway:2024101] CS/DS degradation [Homo sapiens]
(normalReaction)	[FailedReaction:3662344] Defective HEXB does not cleave the terminal GalNAc from DS [Homo sapiens]
(precedingEvent)	[Reaction:1793186] IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9953693] Update Tracker - [Reaction:9638075] HEXB cleaves the terminal GalNAc from DS - v93:[modifyText]
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