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Details on Person UniProt:P97503 Nkx3-2
| Class:Id | ReferenceGeneProduct:96372 |
|---|---|
| _chainChangeLog | chain:1-333 added on Fri February 6 2015 |
| _displayName | UniProt:P97503 Nkx3-2 |
| _timestamp | 2023-11-03 16:06:00 |
| chain | chain:1-333 |
| checksum | D089523714C86BA6 |
| comment | FUNCTION Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus.SUBCELLULAR LOCATION Expressed widely in mesoderm at the gastroduodenal junction (at protein level). Expressed in visceral mesoderm and embryonic skeleton. Expression is restricted to immature proliferative chondrocytes during endochondral ossification.DEVELOPMENTAL STAGE During embryogenesis, expressed in a discrete domain within the mandibular component of the first branchial arch and later in the primordia of middle earassociated bones, the gonium and tympanic ring.SIMILARITY Belongs to the NK-3 homeobox family. |
| description | recommendedName: Homeobox protein Nkx-3.2 alternativeName: Bagpipe homeobox protein homolog 1 alternativeName: Homeobox protein NK-3 homolog B |
| geneName | Nkx3-2 Bapx1 Nkx-3.2 Nkx3b |
| identifier | P97503 |
| isSequenceChanged | FALSE |
| keyword | DNA-binding Homeobox Nucleus Reference proteome Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Nkx3-2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | NKX32_MOUSE A6H6G9 |
| sequenceLength | 333 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:8985314] Nkx3-2 [nucleoplasm] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P97503 Nkx3-2 (96372)
