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Details on Person PTPN7 binds p-T,Y-MAPK

Class:Id	Reaction:9635743
_displayName	PTPN7 binds p-T,Y-MAPK
_doRelease	TRUE
_timestamp	2020-05-27 01:55:17
authored	[InstanceEdit:9662688] Orlic-Milacic, Marija, 2019-09-23 [InstanceEdit:9665057] Rothfels, Karen, 2019-10-28
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9635744] Orlic-Milacic, Marija, 2019-02-08
edited	[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
input	[EntityWithAccessionedSequence:9635737] PTPN7 [cytosol] [Homo sapiens] [DefinedSet:1268261] p-T,Y MAPK dimers [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9635745] Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP) [LiteratureReference:9635753] The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP [LiteratureReference:9635754] Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase [LiteratureReference:9635761] Differential interaction of the tyrosine phosphatases PTP-SL, STEP and HePTP with the mitogen-activated protein kinases ERK1/2 and p38alpha is determined by a kinase specificity sequence and influenced by reducing agents
modified	[InstanceEdit:9635767] Orlic-Milacic, Marija, 2019-02-08 [InstanceEdit:9665057] Rothfels, Karen, 2019-10-28 [InstanceEdit:9665667] Rothfels, Karen, 2019-10-31 [InstanceEdit:9686661] Rothfels, Karen, 2020-05-04 [InstanceEdit:9690154] Rothfels, Karen, 2020-05-27 [InstanceEdit:9690163] Orlic-Milacic, Marija, 2020-05-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PTPN7 binds p-T,Y-MAPK PTPN7 binds phosphorylated ERKs
output	[Complex:9635740] PTPN7:p-T,Y-MAPK dimers [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5674385] p-T,Y MAPKs dimerize [Homo sapiens] [Reaction:5672980] Dissociation of RAS:RAF complex [Homo sapiens] [Reaction:109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 [Homo sapiens] [BlackBoxEvent:109863] Dissociation of p-T,Y-MAPK3:MAP2K1 [Homo sapiens] [BlackBoxEvent:9610154] Dissociation of phosphorylated MAP2Ks and MAPKs [Homo sapiens]
releaseDate	2020-06-10
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9635747] R-HSA-9635743.2
summation	[Summation:9635742] PTPN7 (HePTP) protein tyrosine phosphatase binds to MAPK1 (E...
(hasEvent)	[Pathway:5675221] Negative regulation of MAPK pathway [Homo sapiens]
(precedingEvent)	[Reaction:9635739] PTPN7 dephosphorylates p-T,Y-MAPKs [Homo sapiens]
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No pathways have been reviewed or authored by PTPN7 binds p-T,Y-MAPK (9635743)