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Details on Person PTPN7 dephosphorylates p-T,Y-MAPKs

Class:Id	Reaction:9635739
_displayName	PTPN7 dephosphorylates p-T,Y-MAPKs
_doRelease	TRUE
_timestamp	2020-05-27 01:55:18
authored	[InstanceEdit:9662688] Orlic-Milacic, Marija, 2019-09-23 [InstanceEdit:9665057] Rothfels, Karen, 2019-10-28
catalystActivity	[CatalystActivity:9635771] non-membrane spanning protein tyrosine phosphatase activity of PTPN7:p-T,Y-MAPK dimers [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9635744] Orlic-Milacic, Marija, 2019-02-08
edited	[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
input	[Complex:9635740] PTPN7:p-T,Y-MAPK dimers [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9635753] The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP [LiteratureReference:9635745] Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)
modified	[InstanceEdit:9635784] Orlic-Milacic, Marija, 2019-02-08 [InstanceEdit:9635786] Orlic-Milacic, Marija, 2019-02-08 [InstanceEdit:9663219] Orlic-Milacic, Marija, 2019-09-27 [InstanceEdit:9665058] Rothfels, Karen, 2019-10-28 [InstanceEdit:9665667] Rothfels, Karen, 2019-10-31 [InstanceEdit:9686661] Rothfels, Karen, 2020-05-04 [InstanceEdit:9690154] Rothfels, Karen, 2020-05-27 [InstanceEdit:9690163] Orlic-Milacic, Marija, 2020-05-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PTPN7 dephosphorylates p-T,Y-MAPKs PTPN7 dephosphorylates ERKs
output	[Complex:9635774] PTPN7:p-T-MAPK dimers [cytosol] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:9635743] PTPN7 binds p-T,Y-MAPK [Homo sapiens] [Reaction:5674385] p-T,Y MAPKs dimerize [Homo sapiens]
releaseDate	2020-06-10
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9635748] R-HSA-9635739.2
summation	[Summation:9663217] Protein tyrosine phosphatase PTPN7 (also known as HePTP) dep...
(hasEvent)	[Pathway:5675221] Negative regulation of MAPK pathway [Homo sapiens]
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No pathways have been reviewed or authored by PTPN7 dephosphorylates p-T,Y-MAPKs (9635739)