Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:O53692 esxG
| Class:Id | ReferenceGeneProduct:9635659 |
|---|---|
| _chainChangeLog | initiator methionine:1 for 9635659 added on Fri February 15 2019;chain:2-97 for 9635659 added on Fri February 15 2019;initiator methionine:1 for 9635659 removed on Fri Nov 03 2023;initiator methionine: for 9635659 added on Fri Nov 03 2023;initiator methionine: for 9635659 removed on Fri Aug 15 2025;initiator methionine:1 for 9635659 added on Fri Aug 15 2025 |
| _displayName | UniProt:O53692 esxG |
| _timestamp | 2025-08-15 21:29:55 |
| chain | initiator methionine:1 chain:2-97 |
| checksum | 927527DA610A1637 |
| comment | FUNCTION EsxG, in complex with EsxH, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery. EsxG stabilizes EsxH in the host cytosol.SUBUNIT Forms a tight 1:1 complex with EsxH.INTERACTION Secreted via the ESX-3 / type VII secretion system (T7SS).MISCELLANEOUS To improve expression in E.coli the proteins were cloned as a single protein in the order esxH-esxG with a cleavable thrombin tag (PubMed:19854905).SIMILARITY Belongs to the WXG100 family. CFP-10 subfamily. |
| created | [InstanceEdit:9635645] Pardo, Agustin, 2019-02-06 |
| description | recommendedName: fullName evidence="9"ESAT-6-like protein EsxG alternativeName: fullName evidence="9"Conserved protein TB9.8 |
| geneName | esxG Rv0287 |
| identifier | O53692 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Reference proteome Secreted Virulence |
| modified | [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | esxG |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ESXG_MYCTU F2GM91 I6Y3F0 Q7DA34 |
| sequenceLength | 97 |
| species | [Species:176806] Mycobacterium tuberculosis |
| (referenceEntity) | [EntityWithAccessionedSequence:9635637] EsxG [cytosol] [Mycobacterium tuberculosis] [EntityWithAccessionedSequence:9697317] EsxG [phagocytic vesicle lumen] [Mycobacterium tuberculosis] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O53692 esxG (9635659)
