Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of Infection with Mycobacterium tuberculosis

Class:IdPathwayDiagram:9635549
_displayNameDiagram of Infection with Mycobacterium tuberculosis
_timestamp2020-08-12 15:24:32
created[InstanceEdit:9635550] Pardo, Agustin, 2019-02-05
height1516
modified[InstanceEdit:9635553] Pardo, Agustin, 2019-02-05
[InstanceEdit:9638299] Koile, Daniel, 2019-03-05
[InstanceEdit:9638303] Koile, Daniel, 2019-03-05
[InstanceEdit:9638829] Koile, Daniel, 2019-03-06
[InstanceEdit:9638830] Koile, Daniel, 2019-03-06
[InstanceEdit:9638881] Koile, Daniel, 2019-03-06
[InstanceEdit:9640153] Pardo, Agustin, 2019-03-22
[InstanceEdit:9640154] Pardo, Agustin, 2019-03-22
[InstanceEdit:9640155] Pardo, Agustin, 2019-03-22
[InstanceEdit:9640455] Jassal, Bijay, 2019-03-28
[InstanceEdit:9665116] Jassal, Bijay, 2019-10-29
[InstanceEdit:9666711] Jassal, Bijay, 2019-11-06
[InstanceEdit:9667326] Matthews, Lisa, 2019-11-11
[InstanceEdit:9697091] Jassal, Bijay, 2020-08-05
[InstanceEdit:9697230] Jassal, Bijay, 2020-08-11
[InstanceEdit:9697316] Jassal, Bijay, 2020-08-12
representedPathway[Pathway:9635486] Infection with Mycobacterium tuberculosis [Homo sapiens]
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reactionType="Association"> <Inputs> <Input id="2723" points="2246 233" /> <Input id="2822" points="2075 215" /> </Inputs> <Outputs> <Output id="2823" /> </Outputs> <Properties> <displayName>esxA binds PGK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2824" reactomeId="9636669" points="2149 320, 2148 373, 2148 401" position="2148 373" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2723" points="2250 261" /> <Input id="2825" points="2081 298" /> </Inputs> <Outputs> <Output id="2826" /> </Outputs> <Properties> <displayName>esxA binds ENO1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2828" reactomeId="9636564" points="509 696, 470 714, 420 738" position="470 714" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="3017" points="734 696" /> <Input id="2830" points="586 738" /> </Inputs> <Outputs> <Output id="2831" /> </Outputs> <Properties> <displayName>SapM binds RAB7A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2832" reactomeId="9636560" points="1107 706, 1175 706, 1242 707" position="1175 706" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="2833" points="1038 679" /> <Input id="2834" points="1042 726" /> </Inputs> <Outputs> <Output id="2835" points="1278 676" /> <Output id="2836" points="1373 707" /> <Output id="2838" points="1279 731" /> </Outputs> <Catalysts> <Catalyst id="2837" points="1174 644" /> </Catalysts> <Properties> <displayName>Eis acetylates DUSP16</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2841" reactomeId="9636304" points="1772 765, 1772 779, 1771 831" position="1772 779" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2842" points="1713 675" /> <Input id="2843" points="1849 672" /> </Inputs> <Outputs> <Output id="2844" /> </Outputs> <Properties> <displayName>Mce3E binds MAPK3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2845" reactomeId="9636296" points="1936 760, 1936 774, 1936 831" position="1936 774" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2846" points="2009 671" /> <Input id="2843" points="1866 672" /> </Inputs> <Outputs> <Output id="2847" /> </Outputs> <Properties> <displayName>Mce3E binds MAPK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2848" reactomeId="9635424" points="1900 406, 1899 438, 1899 461" position="1899 438" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2849" points="1851 381" /> <Input id="2850" points="1946 382" /> </Inputs> <Outputs> <Output id="2851" /> </Outputs> <Properties> <displayName>Rv3364c binds cathepsin G</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2852" reactomeId="9635446" points="1736 167, 1735 202, 1735 241" position="1735 202" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2853" points="1682 132" /> <Input id="2854" points="1797 130" /> </Inputs> <Outputs> <Output id="2855" /> </Outputs> <Properties> <displayName>Rv3654c binds SFPQ</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2861" reactomeId="9635609" points="1534 420, 1569 420, 1623 419" position="1569 420" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2862" points="1490 402" /> <Input id="2863" points="1492 440" /> </Inputs> <Outputs> <Output id="2864" /> </Outputs> <Properties> <displayName>Rv3655c binds RNF213</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2865" reactomeId="9636297" points="2090 1292, 2040 1292, 1990 1292" position="2040 1292" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2736" points="2169 1320" /> <Input id="2866" points="2115 1222" /> </Inputs> <Outputs> <Output id="2867" /> </Outputs> <Properties> <displayName>PtpA binds TRIM27</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2873" reactomeId="9636397" points="2104 1383, 2041 1383, 1993 1383" position="2041 1383" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2736" points="2178 1344" /> <Input id="2874" points="2169 1438" /> </Inputs> <Outputs> <Output id="2875" /> </Outputs> <Properties> <displayName>PtpA binds ATP6V1H</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2876" reactomeId="9636242" points="805 205, 804 225, 804 238" position="804 225" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Dissociation"> <Inputs> <Input id="2877" /> </Inputs> <Outputs> <Output id="2878" points="880 271" /> <Output id="2879" points="743 264" /> </Outputs> <Properties> <displayName>PPE2:KPNA1:KPNB1 dissociates, releasing PPE2 into the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2880" reactomeId="9636240" points="595 277, 595 278, 627 372" position="595 278" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2886" points="515 453" /> <Input id="2879" points="683 277" /> </Inputs> <Outputs> <Output id="2882" /> </Outputs> <Properties> <displayName>PPE2 binds NOS2 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2883" reactomeId="9636247" points="1137 176, 1058 176, 853 176" position="1058 176" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="2884" /> </Inputs> <Outputs> <Output id="2877" /> </Outputs> <Properties> <displayName>PPE2:KPNA1:KPNB1 translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2885" reactomeId="9636261" points="515 453, 632 453, 774 453" position="632 453" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="2886" /> </Inputs> <Outputs> <Output id="2887" /> </Outputs> <Inhibitors> <Inhibitor id="2882" points="632 414" /> </Inhibitors> <Properties> <displayName>NOS2 gene produces NOS2 protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2888" reactomeId="9636251" points="1333 176, 1335 176, 1226 176" position="1335 176" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2889" points="1410 200" /> <Input id="2890" points="1413 155" /> </Inputs> <Outputs> <Output id="2884" /> </Outputs> <Properties> <displayName>PPE2 binds KPNA1:KPNB1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2972" reactomeId="9636461" points="2242 1221, 2241 1166, 2239 1090" position="2241 1166" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="2736" points="2202 1316" /> <Input id="2737" points="2281 1265" /> </Inputs> <Outputs> <Output id="2738" /> </Outputs> <Properties> <displayName>PtpA binds Ubiquitin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3000" reactomeId="9636404" points="1249 1385, 1249 1425, 1249 1474" position="1249 1425" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="3001" /> </Inputs> <Outputs> <Output id="3003" /> </Outputs> <Properties> <displayName>LAM translocates from the cell wall to the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="3002" points="1249 1349, 1249 1328" position="1249 1338" lineWidth="1.0" lineColor="255 0 0"> <Inputs> <Input id="3001" /> </Inputs> <Outputs> <Output id="2998" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="3006" reactomeId="9636439" points="2003 1020, 2004 1074, 2004 1112" position="2004 1074" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="3007" points="1957 1008" /> <Input id="3008" points="2053 998" /> </Inputs> <Outputs> <Output id="3009" points="2082 1136" /> <Output id="3010" points="1923 1143" /> </Outputs> <Catalysts> <Catalyst id="2738" points="2195 1075" /> </Catalysts> <Properties> <displayName>PtpA:Ub dephosphorylates p-Y133-VPS33B</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3011" reactomeId="9636396" points="1577 1066, 1632 1066, 1701 1066" position="1632 1066" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="3012" points="1481 1098" /> <Input id="3013" points="1488 1035" /> </Inputs> <Outputs> <Output id="3014" /> </Outputs> <Properties> <displayName>lpdC binds to CORO1A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3015" reactomeId="9636375" points="840 938, 771 882, 771 710" position="771 882" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="3016" /> </Inputs> <Outputs> <Output id="3017" /> </Outputs> <Catalysts> <Catalyst id="3018" points="862 882" /> </Catalysts> <Properties> <displayName>SecA2 transports SapM from cytoplasm to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3020" reactomeId="9636457" points="723 626, 772 625, 824 625" position="772 625" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="3021" points="691 609" /> <Input id="3022" points="678 641" /> </Inputs> <Outputs> <Output id="3023" points="881 604" /> <Output id="3026" points="872 654" /> </Outputs> <Catalysts> <Catalyst id="3017" points="771 682" /> </Catalysts> <Properties> <displayName>SapM dephosphorylates PI3P</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3027" reactomeId="9636684" points="1565 1281, 1621 1281, 1676 1281" position="1621 1281" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="3028" points="1500 1241" /> <Input id="3029" points="1506 1303" /> </Inputs> <Outputs> <Output id="3030" points="1735 1308" /> <Output id="3033" points="1744 1236" /> </Outputs> <Catalysts> <Catalyst id="3031" points="1620 1347" /> </Catalysts> <Properties> <displayName>ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3236" reactomeId="9635461" points="2376 1374, 2376 1331, 2376 1282" position="2376 1331" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="3237" points="2376 1409" /> <Input id="3238" points="2403 1380" /> </Inputs> <Outputs> <Output id="3239" points="2376 1229" /> <Output id="3241" points="2399 1260" /> </Outputs> <Catalysts> <Catalyst id="2736" points="2228 1330" /> </Catalysts> <Properties> <displayName>PtpA dephosphorylates GSK3A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3249" reactomeId="9697057" points="794 1285, 712 1285, 615 1287" position="712 1285" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2819" points="812 1291" /> <Input id="2818" points="816 1275" /> </Inputs> <Outputs> <Output id="2816" /> </Outputs> <Properties> <displayName>esxG binds esxH</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3405" reactomeId="9697077" points="1102 1124, 1163 1124, 1191 1124" position="1163 1124" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="2992" /> </Inputs> <Outputs> <Output id="2994" /> </Outputs> <Catalysts> <Catalyst id="2995" points="1087 1069" /> </Catalysts> <Properties> <displayName>Rv1410c transports lprG:LM,LAM from cytosol to the cell wall</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3439" reactomeId="9697084" points="627 1031, 627 1094, 627 1154" position="627 1094" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Transition"> <Inputs> <Input id="3131" points="679 996" /> <Input id="3132" points="675 1036" /> </Inputs> <Outputs> <Output id="3133" points="681 1207" /> <Output id="3134" points="664 1144" /> </Outputs> <Catalysts> <Catalyst id="3149" points="592 1094" /> </Catalysts> <Properties> <displayName>Defective rpoB in Mtb RNAP transcribes RNA polyanion</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3441" reactomeId="9697085" points="780 1027, 780 1117, 780 1149" position="780 1117" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Transition"> <Inputs> <Input id="3131" points="728 996" /> <Input id="3132" points="730 1035" /> </Inputs> <Outputs> <Output id="3133" points="719 1207" /> <Output id="3134" points="740 1141" /> </Outputs> <Catalysts> <Catalyst id="3135" points="833 1056" /> </Catalysts> <Inhibitors> <Inhibitor id="3452" points="852 1137" /> </Inhibitors> <Properties> <displayName>RNAP transcribes Mtb RNA polyanion</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3450" reactomeId="9697086" points="886 1094, 886 1094, 886 1137" position="886 1094" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="3451" points="919 1063" /> <Input id="3135" points="850 1056" /> </Inputs> <Outputs> <Output id="3452" /> </Outputs> <Properties> <displayName>Rifampicin binds Mtb RNAP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3484" reactomeId="9697064" points="1042 1196, 1042 1196, 1042 1138" position="1042 1196" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2991" points="1086 1252" /> <Input id="2990" points="1000 1255" /> </Inputs> <Outputs> <Output id="2992" /> </Outputs> <Properties> <displayName>lprG binds to LAM,LM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3485" reactomeId="9697070" points="1244 1138, 1199 1222, 1199 1222" position="1199 1222" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Dissociation"> <Inputs> <Input id="2994" /> </Inputs> <Outputs> <Output id="2998" points="1243 1294" /> <Output id="2997" points="1227 1229" /> </Outputs> <Properties> <displayName>lprG dissociates from LAM,LM</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Infection with Mycobacterium tuberculosis (9635549)
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