Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of Transcriptional Regulation by NPAS4

Class:IdPathwayDiagram:9634854
_displayNameDiagram of Transcriptional Regulation by NPAS4
_timestamp2024-11-04 23:44:24
created[InstanceEdit:9634858] Orlic-Milacic, Marija, 2019-01-16
height1301
modified[InstanceEdit:9634877] Orlic-Milacic, Marija, 2019-01-16
[InstanceEdit:9634913] Orlic-Milacic, Marija, 2019-01-16
[InstanceEdit:9634914] Orlic-Milacic, Marija, 2019-01-16
[InstanceEdit:9634920] Orlic-Milacic, Marija, 2019-01-16
[InstanceEdit:9634932] Orlic-Milacic, Marija, 2019-01-16
[InstanceEdit:9634933] Orlic-Milacic, Marija, 2019-01-16
[InstanceEdit:9634942] Orlic-Milacic, Marija, 2019-01-16
[InstanceEdit:9634947] Orlic-Milacic, Marija, 2019-01-16
[InstanceEdit:9635160] Orlic-Milacic, Marija, 2019-01-17
[InstanceEdit:9638162] Orlic-Milacic, Marija, 2019-02-28
[InstanceEdit:9639410] Orlic-Milacic, Marija, 2019-03-11
[InstanceEdit:9639416] Orlic-Milacic, Marija, 2019-03-11
[InstanceEdit:9639583] Orlic-Milacic, Marija, 2019-03-13
[InstanceEdit:9640037] Orlic-Milacic, Marija, 2019-03-20
[InstanceEdit:9640071] Orlic-Milacic, Marija, 2019-03-20
[InstanceEdit:9644884] Orlic-Milacic, Marija, 2019-04-26
[InstanceEdit:9644904] Orlic-Milacic, Marija, 2019-04-26
[InstanceEdit:9644905] Orlic-Milacic, Marija, 2019-04-26
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9769443] Orlic-Milacic, Marija, 2022-03-16
[InstanceEdit:9769444] Orlic-Milacic, Marija, 2022-03-16
[InstanceEdit:9769464] Orlic-Milacic, Marija, 2022-03-16
[InstanceEdit:9769656] Orlic-Milacic, Marija, 2022-03-21
[InstanceEdit:9769671] Orlic-Milacic, Marija, 2022-03-21
[InstanceEdit:9769692] Orlic-Milacic, Marija, 2022-03-21
[InstanceEdit:9769700] Orlic-Milacic, Marija, 2022-03-21
[InstanceEdit:9769712] Orlic-Milacic, Marija, 2022-03-21
[InstanceEdit:9769723] Orlic-Milacic, Marija, 2022-03-21
[InstanceEdit:9769767] Orlic-Milacic, Marija, 2022-03-22
[InstanceEdit:9769774] Orlic-Milacic, Marija, 2022-03-22
[InstanceEdit:9769835] Orlic-Milacic, Marija, 2022-03-22
[InstanceEdit:9769870] Orlic-Milacic, Marija, 2022-03-22
[InstanceEdit:9769871] Orlic-Milacic, Marija, 2022-03-22
[InstanceEdit:9769880] Orlic-Milacic, Marija, 2022-03-22
[InstanceEdit:9769895] Orlic-Milacic, Marija, 2022-03-22
[InstanceEdit:9769906] Orlic-Milacic, Marija, 2022-03-22
[InstanceEdit:9769928] Orlic-Milacic, Marija, 2022-03-22
[InstanceEdit:9769946] Orlic-Milacic, Marija, 2022-03-23
[InstanceEdit:9769996] Orlic-Milacic, Marija, 2022-03-23
[InstanceEdit:9769997] Orlic-Milacic, Marija, 2022-03-23
[InstanceEdit:9770034] Orlic-Milacic, Marija, 2022-03-23
[InstanceEdit:9770059] Orlic-Milacic, Marija, 2022-03-24
[InstanceEdit:9770097] Orlic-Milacic, Marija, 2022-03-24
[InstanceEdit:9770113] Orlic-Milacic, Marija, 2022-03-24
[InstanceEdit:9770176] Orlic-Milacic, Marija, 2022-03-24
[InstanceEdit:9770194] Orlic-Milacic, Marija, 2022-03-25
[InstanceEdit:9770414] Orlic-Milacic, Marija, 2022-04-04
[InstanceEdit:9770511] Orlic-Milacic, Marija, 2022-04-05
[InstanceEdit:9927173] Orlic-Milacic, Marija, 2024-11-04
[InstanceEdit:9927174] Orlic-Milacic, Marija, 2024-11-04
representedPathway[Pathway:9634815] Transcriptional Regulation by NPAS4 [Homo sapiens]
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textPosition="1546 1207"> <Properties> <displayName>MDM2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="726" reactomeId="9769923" position="928 919" bounds="863 888 130 62" textPosition="879 886" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NPAS4:ARNT2,(NPAS4:ARNT,NPAS4:ARNTL):NPAS4 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="785" reactomeId="8948462" position="1275 1007" bounds="1246 982 59 51" textPosition="1257 1009"> <Properties> <displayName>FOS gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="786" reactomeId="9769930" position="1471 1078" bounds="1402 1051 138 55" textPosition="1406 1056" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2):FOS gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="788" reactomeId="450216" position="1286 1113" bounds="1272 1102 29 22" textPosition="1274 1095"> <Properties> <displayName>FOS</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="989" reactomeId="9770027" position="1825 1004" bounds="1782 979 87 51" textPosition="1784 1006"> <Properties> <displayName>IQSEC3 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="990" reactomeId="9770025" position="2059 952" bounds="2004 922 110 60" textPosition="2009 918" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2):IQSEC3 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="992" reactomeId="9770020" position="2304 1032" bounds="2276 1021 56 22" textPosition="2279 1021"> <Properties> <displayName>IQSEC3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1042" reactomeId="6801642" position="1950 733" bounds="1918 708 64 51" textPosition="1930 735"> <Properties> <displayName>PLK2 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1043" reactomeId="9770044" position="2123 673" bounds="2067 642 113 62" textPosition="2074 640" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2):PLK2 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1045" reactomeId="6801636" position="2298 753" bounds="2278 742 40 22" textPosition="2280 742"> <Properties> <displayName>PLK2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1047" reactomeId="9770085" position="1937 335" bounds="1897 310 81 51" textPosition="1898 337"> <Properties> <displayName>SYT10 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1048" reactomeId="9770086" position="2136 420" bounds="2084 388 104 64" textPosition="2086 388" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2):SYT10 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1050" reactomeId="6789226" position="2047 161" bounds="2022 150 51 22" textPosition="2025 150"> <Properties> <displayName>SYT10</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="1051" reactomeId="201753" position="2052 132" bounds="1986 97 132 71" textPosition="1995 109" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>synaptic vesicle membrane</displayName> </Properties> <Components> <Component id="1050" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableGene id="1096" reactomeId="8931792" position="1331 426" bounds="1300 401 62 51" textPosition="1301 428"> <Properties> <displayName>INS gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1097" reactomeId="9770109" position="1456 432" bounds="1406 403 100 59" textPosition="1406 398" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2):INS gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1100" reactomeId="264893" position="1311 157" bounds="1268 148 86 19" textPosition="1272 147"> <Properties> <displayName>INS(25-110)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1102" reactomeId="5641210" position="1944 882" bounds="1915 857 58 51" textPosition="1917 884"> <Properties> <displayName>NAMPT gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1103" reactomeId="9770376" position="2158 822" bounds="2108 791 100 62" textPosition="2108 789" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2):NAMPT gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1105" reactomeId="197188" position="2321 873" bounds="2293 862 56 23" textPosition="2296 862"> <Properties> <displayName>NAMPT</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1229" reactomeId="9770505" position="899 1078" bounds="866 1053 66 51" textPosition="868 1080"> <Properties> <displayName>RET gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1230" reactomeId="9770504" position="1134 1097" bounds="1059 1070 150 55" textPosition="1063 1075" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NPAS4:ARNT2,(NPAS4:ARNT,NPAS4:ARNTL):RET gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1233" reactomeId="8853797" position="976 1283" bounds="958 1274 37 19" textPosition="962 1273"> <Properties> <displayName>RET</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1236" reactomeId="9769961" position="1980 547" bounds="1945 521 70 52" textPosition="1946 548" /> <org.gk.render.RenderableProtein id="1237" reactomeId="9769962" position="2368 579" bounds="2349 567 38 24" textPosition="2351 568" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="5" reactomeId="9634850" points="1001 368, 1041 371, 1081 371" position="1041 371" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="960 410" /> <Input id="7" points="973 353" /> </Inputs> <Outputs> <Output id="8" /> </Outputs> <Properties> <displayName>NPAS4 binds ARNT</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="10" reactomeId="9634861" points="1026 448, 1063 453, 1102 453" position="1063 453" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="978 431" /> <Input id="11" points="1030 416" /> </Inputs> <Outputs> <Output id="12" /> </Outputs> <Properties> <displayName>NPAS4 binds ARNT2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13" reactomeId="9634846" points="1019 499, 1062 500, 1104 501" position="1062 500" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="960 438" /> <Input id="14" points="1003 512" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> <Properties> <displayName>NPAS4 binds ARNTL (BMAL1)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="42" reactomeId="9634884" points="1546 476, 1627 451, 1665 417" position="1627 451" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="49" points="1408 616" /> <Input id="43" points="1610 366, 1608 437" /> </Inputs> <Outputs> <Output id="48" /> </Outputs> <Properties> <displayName>NPAS4 binds CDK5 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="51" points="1164 467, 1349 616" position="1256 541" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="12" /> </Inputs> <Outputs> <Output id="49" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="52" points="1136 386, 1356 616" position="1246 501" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="8" /> </Inputs> <Outputs> <Output id="49" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="66" reactomeId="9634916" points="1610 366, 1612 299, 1627 189" position="1612 299" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="43" /> </Inputs> <Outputs> <Output id="67" /> </Outputs> <Activators> <Activator id="48" points="1666 349" /> </Activators> <Properties> <displayName>CDK5 gene expression is stimulated by NPAS4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="82" reactomeId="9634897" points="1786 539, 1832 522, 1870 460" position="1832 522" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="49" points="1414 616, 1531 523" /> <Input id="83" points="1767 447" /> </Inputs> <Outputs> <Output id="84" /> </Outputs> <Properties> <displayName>NPAS4 binds CDK5R1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="97" reactomeId="9634934" points="1767 447, 1793 334, 1696 78" position="1793 334" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="83" /> </Inputs> <Outputs> <Output id="98" /> </Outputs> <Activators> <Activator id="84" points="1855 390" /> </Activators> <Properties> <displayName>CDK5R1 gene expression is stimulated by NPAS4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="110" reactomeId="9634943" points="1560 108, 1531 79, 1457 65" position="1531 79" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="67" points="1616 159" /> <Input id="98" points="1654 78" /> </Inputs> <Outputs> <Output id="111" /> </Outputs> <Properties> <displayName>MyrG-CDK5R1 binds CDK5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="114" reactomeId="9634886" points="1467 707, 1523 681, 1575 678" position="1523 681" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="49" points="1422 683" /> <Input id="115" points="1586 753" /> </Inputs> <Outputs> <Output id="116" /> </Outputs> <Properties> <displayName>NPAS4 binds RBFOX3 (NeuN) gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="122" reactomeId="9638156" points="1586 753, 1631 747, 1686 761" position="1631 747" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="115" /> </Inputs> <Outputs> <Output id="123" /> </Outputs> <Activators> <Activator id="116" points="1631 712" /> </Activators> <Properties> <displayName>RBFOX3 (NeuN) gene expression is stimulated by NPAS4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="126" points="1169 516, 1337 616" position="1253 566" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="15" /> </Inputs> <Outputs> <Output id="49" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="136" reactomeId="9639567" points="693 639, 633 568, 368 485" position="633 568" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="137" /> </Inputs> <Outputs> <Output id="215" /> </Outputs> <Inhibitors> <Inhibitor id="153" points="589 702, 581 623" /> </Inhibitors> <Activators> <Activator id="155" points="661 810, 526 816, 524 608" /> </Activators> <Properties> <displayName>NPAS4 gene transcription is repressed by KCNIP3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="151" reactomeId="9640060" points="710 706, 689 719, 645 720" position="689 719" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="137" points="693 639" /> <Input id="152" points="746 720" /> </Inputs> <Outputs> <Output id="153" /> </Outputs> <Inhibitors> <Inhibitor id="155" points="688 793" /> </Inhibitors> <Properties> <displayName>KCNIP3 binds NPAS4 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="158" reactomeId="9640063" points="781 812, 780 844, 778 885" position="780 844" lineWidth="1.0"> <Inputs> <Input id="152" points="781 760" /> <Input id="155" stoichiometry="8" points="716 810" /> </Inputs> <Outputs> <Output id="159" stoichiometry="8" points="728 885" /> <Output id="160" points="781 932" /> </Outputs> <Properties> <displayName>Ca2+ binds KCNIP3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="171" reactomeId="9644879" points="1208 343, 1299 370, 1334 343" position="1299 370" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="263" points="1309 509" /> <Input id="172" points="1151 283" /> </Inputs> <Outputs> <Output id="173" /> </Outputs> <Properties> <displayName>NPAS4:ARNT2 binds BDNF gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="185" reactomeId="9644900" points="1151 283, 1231 293, 1150 145" position="1231 293" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="172" /> </Inputs> <Outputs> <Output id="186" /> </Outputs> <Activators> <Activator id="173" points="1291 302" /> <Activator id="570" points="1189 650" /> <Activator id="604" points="1230 605" /> </Activators> <Properties> <displayName>BDNF gene expression is stimulated by NPAS4:ARNT2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="258" reactomeId="9768782" points="297 456, 264 417, 320 172" position="264 417" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="215" /> </Inputs> <Outputs> <Output id="259" /> </Outputs> <Inhibitors> <Inhibitor id="260" points="161 482" /> </Inhibitors> <Properties> <displayName>miR-224 represses NPAS4 mRNA translation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="261" reactomeId="9768788" points="290 618, 244 595, 155 521" position="244 595" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="215" points="314 489" /> <Input id="262" points="295 688" /> </Inputs> <Outputs> <Output id="260" /> </Outputs> <Properties> <displayName>miR-224 binds NPAS4 mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="264" points="1200 459, 1239 466, 1295 509" position="1239 466" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="12" /> </Inputs> <Outputs> <Output id="263" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="265" points="1171 375, 1197 378, 1304 509" position="1197 378" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="8" /> </Inputs> <Outputs> <Output id="263" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="266" points="1200 512, 1270 529" position="1235 520" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="15" /> </Inputs> <Outputs> <Output id="263" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="267" points="1337 571, 1366 616" position="1351 593" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="263" /> </Inputs> <Outputs> <Output id="49" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="295" reactomeId="9768764" points="711 537, 706 505, 694 456" position="706 505" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="137" points="693 639" /> <Input id="296" points="739 526" /> </Inputs> <Outputs> <Output id="297" /> </Outputs> <Properties> <displayName>REST binds promoter and the first intron of NPAS4 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="298" reactomeId="9768762" points="693 639, 655 518, 368 478" position="655 518" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="137" /> </Inputs> <Outputs> <Output id="215" /> </Outputs> <Inhibitors> <Inhibitor id="297" points="686 456" /> </Inhibitors> <Properties> <displayName>NPAS4 gene transcription in non-neuronal cells is repressed by REST</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="312" reactomeId="9768832" points="793 574, 816 526, 743 383" position="816 526" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="137" points="693 639" /> <Input id="313" points="824 593" /> </Inputs> <Outputs> <Output id="314" /> </Outputs> <Properties> <displayName>SRF binds NPAS4 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="315" reactomeId="9768829" points="693 639, 624 488, 368 474" position="624 488" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="137" /> </Inputs> <Outputs> <Output id="215" /> </Outputs> <Activators> <Activator id="314" points="684 372, 614 377" /> </Activators> <Properties> <displayName>SRF stimulates NPAS4 gene transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="344" reactomeId="9769347" points="874 652, 909 607, 868 315, 821 311" position="909 607" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="137" points="693 639" /> <Input id="345" points="907 671" /> </Inputs> <Outputs> <Output id="346" /> </Outputs> <Properties> <displayName>Activated glucocorticoid receptor binds NPAS4 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="360" reactomeId="9769345" points="693 639, 591 470, 368 471" position="591 470" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="137" /> </Inputs> <Outputs> <Output id="215" /> </Outputs> <Inhibitors> <Inhibitor id="346" points="642 323, 583 357" /> </Inhibitors> <Properties> <displayName>Activated glucocorticoid receptor represses NPAS4 gene transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="434" reactomeId="9769143" points="352 160, 860 259, 944 410" position="860 259" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="259" /> </Inputs> <Outputs> <Output id="6" /> </Outputs> <Activators> <Activator id="435" points="848 163" /> </Activators> <Properties> <displayName>NPAS4 translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="445" reactomeId="9769141" points="947 410, 900 263, 897 90, 352 153" position="900 263" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="6" /> </Inputs> <Outputs> <Output id="259" /> </Outputs> <Activators> <Activator id="446" points="970 291" /> </Activators> <Properties> <displayName>NPAS4 translocates to the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="447" reactomeId="9769235" points="189 162, 174 183, 162 233" position="174 183" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="448" points="189 124" /> <Input id="259" points="295 157" /> </Inputs> <Outputs> <Output id="449" /> </Outputs> <Properties> <displayName>MAGED1 binds NPAS4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="566" reactomeId="9769115" points="1049 677, 1187 784, 1179 822" position="1187 784" lineWidth="1.0"> <Inputs> <Input id="6" points="943 438, 913 479" /> <Input id="567" stoichiometry="6" points="1083 622" /> </Inputs> <Outputs> <Output id="592" stoichiometry="6" points="1138 806" /> <Output id="569" points="1155 863" /> </Outputs> <Catalysts> <Catalyst id="570" points="1187 712" /> </Catalysts> <Properties> <displayName>MAPK1,(MAPK3) phosphorylates NPAS4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="647" reactomeId="9768930" points="1484 830, 1545 831, 1600 859" position="1545 831" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="49" points="1397 683" /> <Input id="648" points="1502 876" /> </Inputs> <Outputs> <Output id="649" /> </Outputs> <Properties> <displayName>NPAS4 binds MDM2 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="683" reactomeId="9768925" points="1502 876, 1543 924, 1568 1203" position="1543 924" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="648" /> </Inputs> <Outputs> <Output id="684" /> </Outputs> <Inhibitors> <Inhibitor id="649" points="1595 908" /> </Inhibitors> <Properties> <displayName>MDM2 gene expression is repressed by NPAS4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="725" reactomeId="9768939" points="953 776, 937 834, 931 885" position="937 834" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="263" points="1319 571, 1252 928, 1049 929" /> <Input id="137" points="693 639" /> </Inputs> <Outputs> <Output id="726" /> </Outputs> <Properties> <displayName>NPAS4 binds NPAS4 gene enhancer elements</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="728" reactomeId="9768937" points="693 639, 613 532, 368 481" position="613 532" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="137" /> </Inputs> <Outputs> <Output id="215" /> </Outputs> <Activators> <Activator id="726" points="915 953, 881 1032, 497 1036, 494 586" /> </Activators> <Properties> <displayName>NPAS4 gene transcription is stimulated by NPAS4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="784" reactomeId="9768950" points="1377 971, 1417 1001, 1451 1048" position="1417 1001" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="785" points="1314 984" /> <Input id="49" points="1381 683" /> </Inputs> <Outputs> <Output id="786" /> </Outputs> <Properties> <displayName>NPAS4 binds FOS gene enhancer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="787" reactomeId="9768945" points="1314 984, 1354 1078, 1304 1105" position="1354 1078" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="785" /> </Inputs> <Outputs> <Output id="788" /> </Outputs> <Activators> <Activator id="786" points="1399 1078" /> </Activators> <Properties> <displayName>NPAS4 stimulates FOS gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="988" reactomeId="9769044" points="1900 939, 1956 940, 2001 945" position="1956 940" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="49" points="1439 640, 1570 617, 1843 657" /> <Input id="989" points="1878 981" /> </Inputs> <Outputs> <Output id="990" /> </Outputs> <Properties> <displayName>NPAS4 binds IQSEC3 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="991" reactomeId="9769042" points="1878 981, 2062 1029, 2273 1031" position="2062 1029" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="989" /> </Inputs> <Outputs> <Output id="992" /> </Outputs> <Activators> <Activator id="990" points="2060 985" /> </Activators> <Properties> <displayName>NPAS4 stimulates IQSEC3 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1041" reactomeId="9769165" points="1908 629, 1999 649, 2064 662" position="1999 649" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1042" points="1991 710" /> <Input id="49" points="1439 631, 1564 588" /> </Inputs> <Outputs> <Output id="1043" /> </Outputs> <Properties> <displayName>NPAS4 binds PLK2 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1044" reactomeId="9769177" points="1991 710, 2112 765, 2275 754" position="2112 765" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1042" /> </Inputs> <Outputs> <Output id="1045" /> </Outputs> <Activators> <Activator id="1043" points="2119 707" /> </Activators> <Properties> <displayName>NPAS4 stimulates PLK2 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1046" reactomeId="9770072" points="1827 558, 2029 475, 2081 446" position="2029 475" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="49" points="1425 616, 1539 549" /> <Input id="1047" points="1987 312, 1983 477" /> </Inputs> <Outputs> <Output id="1048" /> </Outputs> <Properties> <displayName>NPAS4 binds SYT10 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1049" reactomeId="9769249" points="1987 312, 2054 312, 2047 175" position="2054 312" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1047" /> </Inputs> <Outputs> <Output id="1050" /> </Outputs> <Activators> <Activator id="1048" points="2111 385" /> </Activators> <Properties> <displayName>NPAS4 stimulates SYT10 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1095" reactomeId="9769302" points="1394 508, 1456 506, 1456 465" position="1456 506" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="49" points="1384 616" /> <Input id="1096" points="1371 403" /> </Inputs> <Outputs> <Output id="1097" /> </Outputs> <Properties> <displayName>NPAS4 binds INS gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1099" reactomeId="9769307" points="1371 403, 1457 379, 1464 330, 1451 164, 1357 159" position="1464 330" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1096" /> </Inputs> <Outputs> <Output id="1100" /> </Outputs> <Inhibitors> <Inhibitor id="1097" points="1480 400, 1518 356" /> </Inhibitors> <Properties> <displayName>NPAS4 represses INS gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1101" reactomeId="9769316" points="1913 832, 2011 786, 2105 809" position="2011 786" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1102" points="1982 859" /> <Input id="49" points="1439 636, 1570 604, 1853 643" /> </Inputs> <Outputs> <Output id="1103" /> </Outputs> <Properties> <displayName>NPAS4 binds NAMPT gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1104" reactomeId="9769323" points="1982 859, 2159 897, 2290 877" position="2159 897" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1102" /> </Inputs> <Outputs> <Output id="1105" /> </Outputs> <Activators> <Activator id="1103" points="2158 856" /> </Activators> <Properties> <displayName>NPAS4 stimulates NAMPT gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1228" reactomeId="9769419" points="1287 929, 1204 1001, 1154 1067" position="1204 1001" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1229" points="941 1055" /> <Input id="263" points="1321 571" /> </Inputs> <Outputs> <Output id="1230" /> </Outputs> <Properties> <displayName>NPAS4 binds RET gene enhancer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1232" reactomeId="9769418" points="941 1055, 975 1117, 975 1271" position="975 1117" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1229" /> </Inputs> <Outputs> <Output id="1233" /> </Outputs> <Activators> <Activator id="1230" points="1056 1106" /> </Activators> <Properties> <displayName>NPAS4 stimulates RET gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1235" reactomeId="9769014" points="2024 523, 2057 611, 2346 580" position="2057 611" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1236" /> </Inputs> <Outputs> <Output id="1237" /> </Outputs> <Activators> <Activator id="49" points="1439 623, 1538 571" /> </Activators> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Transcriptional Regulation by NPAS4 (9634854)
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