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Details on Person CSF3R gene expression is enhanced by SPI1 (PU.1), CEBPA, and DEK

Class:Id	BlackBoxEvent:9634429
_displayName	CSF3R gene expression is enhanced by SPI1 (PU.1), CEBPA, and DEK
_doRelease	TRUE
_timestamp	2019-03-10 13:13:16
authored	[InstanceEdit:9617115] May, Bruce, 2018-08-16
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9634435] May, Bruce, 2019-01-10
edited	[InstanceEdit:9617115] May, Bruce, 2018-08-16
inferredFrom	[BlackBoxEvent:9634443] Csf3r gene expression is enhanced by Cebpa [Mus musculus]
input	[EntityWithAccessionedSequence:9617074] CSF3R gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9617236] C/EBPα and DEK coordinately regulate myeloid differentiation [LiteratureReference:9617189] PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells [LiteratureReference:9625579] Restoration of C/EBPalpha expression in a BCR-ABL+ cell line induces terminal granulocytic differentiation
modified	[InstanceEdit:9639379] May, Bruce, 2019-03-10 [InstanceEdit:9639380] May, Bruce, 2019-03-10 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CSF3R gene expression is enhanced by SPI1 (PU.1), CEBPA, and DEK
output	[EntityWithAccessionedSequence:6787734] CSF3R [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8865505] SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A [Homo sapiens] [Reaction:8865498] KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark [Homo sapiens] [BlackBoxEvent:9622367] CEBPA mRNA is translated to yield CEBPA protein [Homo sapiens] [BlackBoxEvent:9616243] CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9617195] Positive gene expression regulation by 'CSF3R gene:SPI1:CEPBA dimer:DEK [nucleoplasm]'
regulationReference	[RegulationReference:9641314] Positive gene expression regulation by 'CSF3R gene:SPI1:CEPBA dimer:DEK [nucleoplasm]' C/EBPα and DEK coordinately regulate myeloid differentiation
releaseDate	2019-06-12
reviewed	[InstanceEdit:9639377] Skokowa, Julia, 2019-03-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9634458] R-HSA-9634429.2
summation	[Summation:9622471] SPI1 (PU.1) and CEBPA bind the promoter of the CSF3R (G-CSFR...
(hasEvent)	[Pathway:9616222] Transcriptional regulation of granulopoiesis [Homo sapiens]
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No pathways have been reviewed or authored by CSF3R gene expression is enhanced by SPI1 (PU.1), CEBPA, and DEK (9634429)